Leu(8,18)- Ile(12)- Ala(20)- MePhe(26)- Tyr(28)- Pro(29)- ANF (4-28)

an ANP analog with natriuretic, diuretic, and hypotensive properties; causes decrease in distal fractional tubular reabsorption

Also Known As:

ANF (4-28), Leu(8,18)-Ile(12)-Ala(20)-MePhe(26)-Tyr(28)-Pro(29)-; (8,18-leucyl-12-isoleucyl-20-alanyl-26-methylphenylalanyl-28-tyrosyl)-29-prolyl-ANP(4-28); (Leu(8,18)-Ile(12)-D-Ala(20)-MePhe(26)-D-Tyr(28))-Pro(29)-atrial natriuretic peptide (4-28); P-ANP; atrial natriuretic factor (4-28), (leucyl(8)-isoleucyl(12)-leucyl(18)-D-alanyl(20)-methylphenylalanyl(26)-D-tyrosyl(28))prolyl(29)-; atrial natriuretic factor (4-28),(Leu(8)-Ile(12)-Leu(18)-D-Ala(20)-MePhe(26)-D-Tyr(28))Pro(29)-

Networked: 5 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bech, Jesper Nørgaard: 1 article (04/2012)
2.	Graffe, Carolina Cannillo: 1 article (04/2012)
3.	Lauridsen, Thomas Guldager: 1 article (04/2012)
4.	Pedersen, Erling Bjerregaard: 1 article (04/2012)
5.	Rittig, Søren: 1 article (06/2010)

Related Diseases

1.	Autosomal Dominant Polycystic Kidney (ADPKD) 04/15/2012 - "To study the function and regulation of the aquaporin-2 water channel (AQP2) and the epithelial sodium channel (ENaC) in autosomal dominant polycystic kidney disease (ADPKD), we measured urinary excretion of AQP2 (u-AQP2), the β-subunit of ENaC (u-ENaC(β)), cAMP (u-cAMP), and prostaglandin E(2) (u-PGE(2)); free water clearance (C(H2O)); fractional sodium excretion (FE(Na)); and plasma vasopressin (p-AVP), renin (p-Renin), angiotensin II (p-ANG II), aldosterone (p-Aldo), and atrial and brain natriuretic peptide (p-ANP, p-BNP) in patients with ADPKD and healthy controls during 24-h urine collection and after hypertonic saline infusion during high sodium intake (HS; 300 mmol sodium/day) and low sodium intake (LS; 30 mmol sodium/day). "
2.	Shock 07/01/1988 - "The purpose of this study was to clarify whether plasma ANP levels (p-ANP) are abnormal in TAH animals, and if ANP plays an important role in circulatory failure in TAH animals. "
3.	Hyperthyroidism 03/01/1997 - "No study investigating serum ACE together with p-ANP levels has been performed in experimental hyperthyroid and hypothyroid rabbits. " 03/01/1997 - "Our results indicate that not only p-ANP but also serum ACE activity was markedly increased in experimental hyperthyroid rabbits. " 03/01/1997 - "Serum ACE, plasma renin activity (PRA) and p-ANP were higher in hyperthyroid rabbits and lower in hypothyroid rabbits than in euthyroid rabbits. " 03/01/1997 - "It is known that serum angiotensin-converting enzyme (ACE), and plasma atrial natriuretic peptide (p-ANP) levels increase in hyperthyroidism. "
4.	Vasovagal Syncope 01/01/1991 - "Two subjects had vasovagal syncope 30-60 min after injection of P-ANP. "
5.	Enuresis 06/01/2010 - "In both controls and patients with enuresis, DSP at 10:00 h resulted in a marked fall in MAP and HR, a rise in pulse pressure (PP) and estimated plasma volume (PV) and a significant suppression of P(AVP), P(ANGII) and S(ALDO), whereas P(ANP) increased. "

Related Drugs and Biologics

1.	Renin
2.	Atrial Natriuretic Factor (ANF)
3.	Epithelial Sodium Channels
4.	Aquaporin 2
5.	Aquaporins (Water Channels)
6.	Brain Natriuretic Peptide (Natrecor)
7.	Vasopressins (Vasopressin)
8.	Sodium
9.	Prostaglandins E
10.	Prostaglandins