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lufironil
structure given in first source; inhibits CCl4-induced liver fibrosis in rats and inhibits proline hydroxylase
Also Known As:
HOE 077; HOE-077; pyridine-2,4-dicarboxylic-di-(2-methoxyethyl)amide; 2,4-Pyridinedicarboxamide, N,N'-bis(2-methoxyethyl)-
Networked:
8
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
lufironil: 8
Related Diseases
1.
Liver Cirrhosis (Hepatic Cirrhosis)
07/01/1997 - "
A prolyl 4-hydroxylase inhibitor (HOE 077) prevented pig serum-induced rat liver fibrosis by inhibiting stellate cell activation.
"
07/01/1997 - "
Prolyl 4-hydroxylase inhibitor (HOE 077) inhibits pig serum-induced rat liver fibrosis by preventing stellate cell activation.
"
01/01/1991 - "
S 0885 and HOE 077 inhibit CCl4-induced liver fibrosis in rats, as shown by significantly reduced hydroxyproline content of the liver and improved liver histology.
"
06/01/1999 - "
Prolyl 4-hydroxylase inhibitor (HOE 077) prevents TIMP-1 gene expression in rat liver fibrosis.
"
07/01/1997 - "
The aim of this study was to investigate the effect and mechanism of fibrosuppression by a newly synthesized prolyl 4-hydroxylase inhibitor [HOE 077, 2, 4-pyridine dicarboxylic acid bis [(2-methoxyethyl) amide]] on pig serum-induced liver fibrosis in the rat.
"
2.
Fibrosis (Cirrhosis)
01/01/1991 - "
They show HOE 077 to be a promising agent for the inhibition of hepatic fibrosis.
"
05/01/1994 - "
In addition, almost all anti-fibrotic agents, except HOE 077, are neither liver-nor fibrosis-specific.
"
06/01/1999 - "
HOE 077 (200 ppm) prevented fibrosis by inhibiting the expression of liver type I procollagen and TIMP-1 mRNAs, with liver hydroxyroline content correlated with the reduction in activated stellate cells.
"
04/01/1996 - "
HOE 077 at doses up to 200 ppm prevented fibrosis in a dose-dependent manner, as indicated by reduced hydroxyproline content in liver as well as inhibition of increased serum fibrotic markers (PIIIP, 7S, hyaluronic acid).
"
06/01/1999 - "
HOE 077 prevents fibrosis by inhibiting proline hydroxylation and stellate cell activation, resulting in reduced expression of procollagen and TIMP-1 mRNAs.
"
3.
Drug-Related Side Effects and Adverse Reactions
07/01/1994 - "
It was not due to drug toxicity, and it was not caused by any endogenous substrate produced under the influence of Lufironil.
"
Related Drugs and Biologics
1.
Hydroxyproline (4 Hydroxyproline)
2.
pyridine-2,4-dicarboxylic-diethylamide
3.
Prolyl Hydroxylases (Prolyl Hydroxylase)
4.
Amides
5.
Acids
6.
Procollagen
7.
Tissue Inhibitor of Metalloproteinase-1
8.
Proline (L-Proline)
9.
Hyaluronic Acid (Hyaluronan)
10.
Glutathione Transferase (Glutathione S-Transferase)