KC 764

structure given in first source; reduces myocardial infarct size, MPO activity, and the activity of arachidonic acid, thromboxane B2 synthesis, plasma glutamate oxalo-acetate transaminase, lactate dehydrogenase, and creatine kinase

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Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Ischemia 11/01/1994 - "[Protective effects of KC-764 on short-term forebrain ischemia in gerbils]." 11/01/1994 - "Behavior recovery time after ischemia was 11.4 +/- 2.8 minutes in the KC-764 group versus 87.3 +/- 13.4 minutes in the control group (p < 0.05). " 11/01/1994 - "KC-764, developed as a cyclo-oxygenase inhibitor, was administered to gerbils in a dose of 10 mg/kg, i.p., before subjecting them to 5-minute bilateral forebrain ischemia in order to determine whether it would have any protective effects. "
2.	Ischemic Stroke 06/01/1994 - "We confirmed that KC-764 at a dose of 20 to 40 mg/day is an effective antiplatelet agent and a good candidate for a trial to see if it is feasible for long-term use for the prevention of ischemic stroke in high-risk patients."
3.	Thrombosis (Thrombus) 01/01/1992 - "KC-764 prevented collagen- and AA-induced thrombosis at more than 1 mg/kg p.o. "
4.	Myocardial Infarction 01/01/1992 - "Myocardial infarct size, MPO activity in the infarcted region and plasma glutamate oxalo-acetate transaminase, lactate dehydrogenase and creatine kinase were significantly suppressed by treatment with KC-764 (2 mg/kg i.v.), but not by ASA (10 mg/kg i.v.). "
5.	Infarction (Infarctions) 01/01/1992 - "The effects of KC-764 (2-methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine, CAS 94457-09-7) on infarct size, myeloperoxidase (MPO) activity and plasma prostanoid levels were studied using coronary artery occlusion (1 h)-reperfusion (3 h) model in rabbits, comparing with acetylsalicylic acid (ASA). "

Related Drugs and Biologics

1.	Cyclooxygenase Inhibitors
2.	Platelet Aggregation Inhibitors (Antiplatelet Drugs)
3.	Glutamic Acid (Glutamate)
4.	Prostaglandins
5.	Peroxidase (Myeloperoxidase)
6.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
7.	Creatine Kinase (Creatine Phosphokinase)
8.	Collagen
9.	Aspirin (Acetylsalicylic Acid)
10.	Transaminases (Aminotransferases)