DAU 6285

Also Known As:

DAU-6285; endo-6-methoxy-8-methyl-8-azabicyclo(3.2.1)oct-3-yl-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylate HCl; 1H-Benzimidazole-1-carboxylic acid, 2,3-dihydro-6-methoxy-2-oxo-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, monohydrochloride, endo-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - DAU 6285: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - DAU 6285: 3

Related Diseases

1.	Tachycardia (Tachyarrhythmias) 03/23/1993 - "The novel 5-HT4 receptor antagonist DAU 6285 antagonizes 5-hydroxytryptamine-induced tachycardia in pigs."
2.	Hyperventilation 01/01/1996 - "The 5-hydroxytryptamine-induced hyperventilation was blocked by the 5-HT3-receptor antagonists metoclopramide (1.0 mg.kg-1) or MDL72222 (1.0 mg.kg-1), and was insensitive to the 5-HT1/2-receptor antagonist methysergide (3.0 mg.kg-1) and to the 5-HT4-receptor antagonist DAU 6285 CL (3.0 mg.kg-1). "
3.	Diarrhea 11/01/1994 - "DAU 6285 significantly inhibited 16,16-dimethyl prostaglandin E2-induced diarrhea at the highest dose (3 mg/kg i.p.). " 11/01/1994 - "Pretreatment (5 min before 5-HTP) with DAU 6285, a marginally selective 5-HT4 receptor antagonist, significantly inhibited 5-HTP-induced diarrhea (ID50, 0.58 mg/kg i.p.). "

Related Drugs and Biologics

1.	5-HT4 Serotonin Receptors
2.	Prostaglandins
3.	Metoclopramide (Reglan)
4.	Methysergide (Sansert)