ikarugamycin

structure given in first source; an antiprotozoal antibiotic isolated from Streptomyces phaeochromogenes ikaruganensis; inhibits the uptake of oxidized LDL in macrophage J774

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Liu, Jinhui: 2 articles (09/2020 - 01/2020)
2.	Adekola, Adewole A: 1 article (09/2021)
3.	Aklilu, Erkihun: 1 article (09/2021)
4.	Kamaruzzaman, Nor Fadhilah: 1 article (09/2021)
5.	Mergani, Ahmed Elmontaser: 1 article (09/2021)
6.	Mohamad, Maizan: 1 article (09/2021)
7.	Mohammedsalih, Khalid M: 1 article (09/2021)
8.	Saeed, Shamsaldeen Ibrahim: 1 article (09/2021)
9.	Asakawa, Takehito: 1 article (09/2021)
10.	Hikichi, Rie: 1 article (09/2021)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2021 - "Ikarugamycin (IK) is an antibiotic which has been reported to have a variety of functions, such as inhibition of clathrin-mediated endocytosis (CME), anti-tumor effects and regulation of the immune system. " 09/01/2020 - "Furthermore, five compounds with potential anti-tumor effects were selected, including ciclopirox, ikarugamycin, vincamine, mevalolactone, and thiamazole. "
2.	Thyroid Neoplasms (Thyroid Cancer) 01/01/2020 - "Finally, four small molecules that could reverse the gene expression induced by thyroid cancer, namely ikarugamycin, adrenosterone, hexamethonium bromide and clofazimine, were obtained in the CMap database. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2020 - "Ikarugamycin inhibits pancreatic cancer cell glycolysis by targeting hexokinase 2."
4.	Leukemia 05/10/2011 - "Ikarugamycin induces DNA damage, intracellular calcium increase, p38 MAP kinase activation and apoptosis in HL-60 human promyelocytic leukemia cells."
5.	Infections 09/25/2021 - "Antibacterial Activity of Ikarugamycin against Intracellular Staphylococcus aureus in Bovine Mammary Epithelial Cells In Vitro Infection Model."

Related Drugs and Biologics

1.	Ciclopirox (Loprox)
2.	p38 Mitogen-Activated Protein Kinases
3.	Thapsigargin
4.	Hexamethonium (Hexamethonium Bromide)
5.	Vincamine
6.	Methimazole (Thiamazole)
7.	Hexokinase
8.	Clofazimine (Lamprene)
9.	Clathrin
10.	Calcium