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KH 1060

structure given in first source; a new 20-epi-vitamin D3 analog
Also Known As:
20-epi-22-oxa-24a-homo-26,27-dimethyl-1alpha,25-dihydroxyvitamin D3; KH-1060; KH1060; 1,3-Cyclohexanediol, 5-((1-(1-((4-ethyl-4-hydroxyhexyl)oxy)ethyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-, (1S-(1alpha(S*),3abeta,4E(1S*,3R*,5Z),7aalpha))-
Networked: 43 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Takeda, Ken: 2 articles (06/2009 - 12/2002)
2. Shimizu, Takahisa: 2 articles (06/2009 - 12/2002)
3. Stio, Maria: 2 articles (07/2006 - 03/2002)
4. d'Albasio, Giuseppe: 2 articles (07/2006 - 03/2002)
5. Treves, Cristina: 2 articles (07/2006 - 03/2002)
6. Binderup, Lise: 2 articles (02/2003 - 01/2003)
7. Treves, C: 2 articles (06/2001 - 02/2001)
8. Stio, M: 2 articles (06/2001 - 02/2001)
9. Fazel, Nasim: 1 article (06/2015)
10. Guo, Miao: 1 article (01/2011)

Related Diseases

1. Lichen Planus (Lichen Ruber Planus)
2. Breast Neoplasms (Breast Cancer)
09/01/1996 - "In human breast cancer cells, MCF-7, the half-maximal gene activation values for KH1060 and seven of its structural precursors were determined on a DR3-type VD response element. "
07/01/1995 - "In conclusion, the data indicate that KH 1060 is an extremely potent 1,25D3 analogue inducing differentiation of all six breast cancer lines and potently inhibiting clonal growth of four of them with concomitant decreased bcl-2 and cell cycle arrest at G0/G1.(ABSTRACT TRUNCATED AT 400 WORDS)"
07/01/1995 - "Dose-response studies showed that KH 1060 was the most potent analogue, because it was able to induce differentiation in all seven breast cancer cell lines (measured by lipid staining) and to suppress more than 50% clonal proliferation (ED50) at 10(-10) M in all cell lines, except MDA-MB-436 and BT-20. "
09/04/1996 - "In human breast cancer MCF-7 cells, we studied the growth-inhibitory activities of a set of 8 analogues that cover conservative structural changes from 20-epi-VD (MC1288) to KH1060. "
07/01/1995 - "We have studied the in vitro biological activities and mechanism of action of 1,25-dihydroxyvitamin D3 (1,25D3) and four potent 1,25D3 analogues [20-epi-22oxa-24a,26a,27a-tri-homo-1,25(OH)2D3 (KH 1060); 20-epi-1,25(OH)2D3; 1,25(OH)2-16ene-D3; and 1,25(OH)2-16ene-23yne-D3] on proliferation and differentiation of estrogen receptor-negative (MDA-MB-436, BT-20, SK-BR-3, and MDA-MB-231), estrogen receptor-weakly positive (BT474), and estrogen receptor-positive (MCF-7) breast cancer cell lines. "
3. Osteosarcoma (Osteogenic Sarcoma)
4. Bone Resorption
5. Leukemia

Related Drugs and Biologics

1. Vitamin D
2. seocalcitol
3. Cholecalciferol (Vitamin D3)
4. hydroxide ion
5. Calcitriol (Calcijex)
6. Tamoxifen
7. Asp(5)- oxytocin (OXA)
8. Tretinoin (Retinoic Acid)
9. Estrogen Receptor Modulators (Antiestrogen)
10. Calcitriol Receptors (Calcitriol Receptor)

Related Therapies and Procedures

1. Aftercare (After-Treatment)
2. Islets of Langerhans Transplantation
3. Homologous Transplantation (Allograft)
4. Heterologous Transplantation (Xenotransplantation)
5. Intraperitoneal Injections