|1.||Lefkowitz, Robert J: 5 articles (05/2009 - 10/2004)|
|2.||Halushka, Perry V: 4 articles (10/2011 - 01/2008)|
|3.||Pei, Gang: 4 articles (08/2008 - 02/2003)|
|4.||Fan, Hongkuan: 3 articles (10/2011 - 01/2008)|
|5.||Cook, James A: 3 articles (10/2011 - 01/2008)|
|6.||Shenoy, Sudha K: 3 articles (07/2005 - 10/2004)|
|7.||Luttrell, Louis M: 2 articles (10/2011 - 07/2010)|
|8.||Borg, Keith T: 2 articles (10/2011 - 01/2008)|
|9.||Rosanò, Laura: 2 articles (08/2010 - 02/2009)|
|10.||Bagnato, Anna: 2 articles (08/2010 - 02/2009)|
07/01/2005 - "To our knowledge this is the first study demonstrating a defined molecular role of beta-arrestin with direct relevance to cell growth and cancer."
01/31/2006 - "These results show that the prostaglandin E/beta-arrestin 1/c-Src signaling complex is a crucial step in PGE(2)-mediated transactivation of the EGFR and may play a pivotal role in tumor metastasis. "
12/01/2009 - "PAR2 also uniquely triggers tumor cell migration by G protein-independent pathways through beta-arrestin scaffolding. "
09/05/2003 - "We have reported previously that protease-activated receptor-2 (PAR-2), a proinflammatory receptor that is highly expressed in motile cells such as neutrophils, macrophages, and tumor cells, is one of a growing family of receptors that utilizes a beta-arrestin-dependent mechanism for activation of the 42-44-kDa members of the MAPK family (extracellular signal-regulated kinases 1 and 2; ERK1/2). "
02/21/2003 - "Oncoprotein Mdm2 is a master negative regulator of the tumor suppressor p53 and has been recently shown to regulate the ubiquitination of beta-arrestin 2, an important adapter and scaffold in signaling of G-protein-coupled receptors (GPCRs). "
|3.||Breast Neoplasms (Breast Cancer)
01/01/2009 - "Breast cancer, beta-arrestin, opioid. "
07/01/2009 - "Thus, our data show a novel role for beta-arrestin/Ral signaling in mediating LPA-induced breast cancer cell migration and invasion, two important processes in metastasis."
12/01/2009 - "Here we report for the first time on the role of GPCR serine/threonine kinase (GRK)2 and beta-arrestin in regulating GPR54 signaling in human embryonic kidney (HEK) 293 cells, a model cell system for studying the molecular regulation of GPCRs, and genetically modified MDA MB-231 cells, an invasive breast cancer cell line expressing about 75% less beta-arrestin-2 than the control cell line. "
07/01/2009 - "Beta-arrestin/Ral signaling regulates lysophosphatidic acid-mediated migration and invasion of human breast tumor cells."
12/31/2004 - "Here we investigate the role of PAR-2 in the constitutive migration of a metastatic breast cancer cell line, MDA MB-231, and use small interfering RNA to determine the contribution of each beta-arrestin to this process. "
01/01/2008 - "These studies demonstrate that beta-arrestin 2 is a negative regulator of PMN activation and pulmomary leukosequestration in response to polymicrobial sepsis."
07/01/2010 - "Our data demonstrate that beta-arrestin 2 functions to negatively regulate the inflammatory response in polymicrobial sepsis."
07/01/2010 - "We hypothesized that beta-arrestin 2 is a critical modulator of inflammatory response in experimental sepsis. "
07/01/2010 - "Beta-arrestin 2 negatively regulates sepsis-induced inflammation."
12/24/1999 - "Moreover, they suggest that inhibition of beta-arrestin 2 function might lead to enhanced analgesic effectiveness of morphine and provide potential new avenues for the study and treatment of pain, narcotic tolerance, and dependence."
01/01/2013 - "Furthermore, although this pain model did not alter Ca2+ current density, the contribution of N-type Ca2+ channels to the total current appeared to be regulated by the presence of beta-arrestin 2. Our results indicate that there is an upregulation of delta opioid receptor function following chronic pain. "
|1.||GTP-Binding Proteins (G-Protein)
|3.||Messenger RNA (mRNA)
|4.||Morphine (MS Contin)
|5.||G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
|7.||beta Adrenergic Receptors
|10.||Proteins (Proteins, Gene)
|1.||Heterologous Transplantation (Xenotransplantation)