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3-methylsulfonyl-4-piperidinobenzoyl guanidine

structure given in first source; a potent inhibitor of the Na+/H+ exchanger
Also Known As:
(3-methylsulphonyl-4-piperidinobenzoyl)guanidine methanesulphonate; HOE 694; HOE-694; HOE694
Networked: 34 relevant articles (7 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Tsai, Chien-Sung: 5 articles (08/2015 - 05/2002)
2. Loh, Shih-Hurng: 5 articles (08/2015 - 05/2002)
3. Chen, Wei-Hwa: 3 articles (09/2002 - 05/2002)
4. Jin, Jong-Shiaw: 3 articles (09/2002 - 05/2002)
5. Lee, Chung-Yi: 2 articles (08/2015 - 10/2014)
6. Tsai, Yi-Ting: 2 articles (08/2015 - 10/2014)
7. Chuang, Chao-Chin: 2 articles (08/2015 - 06/2002)
8. Cheng, Tzu-Hurng: 2 articles (10/2014 - 05/2002)
9. Chao, Chao-Ming: 2 articles (09/2002 - 06/2002)
10. Tse, Chung M: 1 article (10/2015)

Related Diseases

1. Ischemia
2. Reperfusion Injury
3. Acidosis
4. Ventricular Fibrillation
02/01/1995 - "HOE694 (10 microM) was partially effective when infused during reperfusion alone (ventricular fibrillation incidence reduced from 83% to 42%). "
02/01/1995 - "The novel NHE-1 selective Na+/H+ exchange inhibitor HOE694 (10 microM), when infused into the left coronary bed before ischaemia (concomitantly with 10 microM phenylephrine) and throughout reperfusion, reduced the incidence of reperfusion induced ventricular fibrillation from 83% to 25%*. "
06/01/1993 - "In these animals, pretreatment with Hoe 694 caused a dose-dependent reduction of ventricular premature beats and ventricular tachycardia as well as a complete suppression of ventricular fibrillation down to doses of 0.1 mg kg-1, i.v. Blood pressure and heart rate remained unchanged. "
01/01/2001 - "Ischemic contracture, which typically develops during ventricular fibrillation, was ameliorated by HOE-694 when either a bicarbonate-buffered (20 +/- 7 mm Hg vs 15 +/- 5 mm Hg, P <.05) or a HEPES-buffered (14 +/- 5 mm Hg vs 10 +/- 3 mm Hg, P <.04) perfusate was used. "
01/01/2001 - "We used an isolated rat heart model to investigate whether inhibition of the sodium-hydrogen exchanger isoform-1 (with the benzoylguanidine derivatives HOE-694 and cariporide) with or without concomitant inhibition of the sodium-bicarbonate co-transporter (with perfusate buffered with N-2-hydroxyethylpiperazine-N-2-ethanesulfonic acid [HEPES]) during ischemia and ventricular fibrillation could ameliorate functional myocardial abnormalities presumed to limit cardiac resuscitability. "
5. Contracture

Related Drugs and Biologics

1. Amiloride (Midamor)
2. ethylisopropylamiloride (EIPA)
3. cariporide
4. Veratrine
5. Quinidine (Chinidin)
6. Lidocaine (Xylocaine)
7. Flecainide (Tambocor)
8. Mesylates (Mesylate)
9. 3',4'-dichlorobenzamil
10. HEPES

Related Therapies and Procedures

1. Induced Heart Arrest (Cardioplegia)