8-guanidino-octanoyl-Asp-Phe

structure given in first source; a stable analog of Arg-Gly-Asp (RGD) amino acid sequence; represents a novel class of glycoprotein IIb/IIIa inhibitors

Also Known As:

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Thrombosis (Thrombus) 03/01/1993 - "SC-49992 inhibits ex vivo platelet aggregation, prevents occlusive thrombus formation in a canine model of arterial thrombosis, and prevents rethrombosis after thrombolysis. " 03/01/1993 - "Platelet GPIIb/IIIa receptor inhibition by SC-49992 prevents thrombosis and rethrombosis in the canine carotid artery." 03/01/1993 - "The present study examined the ability of SC-49992 (SC), a GPIIb/IIIa receptor antagonist, to prevent thrombosis in a canine model of carotid artery thrombosis. " 12/01/1993 - "SC-49992, a mimetic of the peptide arginine-glycine-aspartic acid-phenylalanine that blocks platelet aggregation, enhances recombinant tissue plasminogen activator-induced thrombolysis and prevents reocclusion in a canine model of coronary artery thrombosis."
2.	Carotid Artery Thrombosis 03/01/1993 - "The present study examined the ability of SC-49992 (SC), a GPIIb/IIIa receptor antagonist, to prevent thrombosis in a canine model of carotid artery thrombosis. "
3.	Proteinuria 09/01/1994 - "In contrast, blockade of the PLT Fg receptor, alpha IIb beta 3, with the RGD peptidomimetic SC-49992 decreased proteinuria (approximately 90%) without substantially altering the influx of PMNs or PLTs. "

Related Drugs and Biologics

1.	Peptidomimetics
2.	Tissue Plasminogen Activator (Alteplase)
3.	Phenylalanine (L-Phenylalanine)
4.	Peptides (Polypeptides)
5.	aspartic acid glycine arginine