Trypanosoma cruzi cruzain

amino acid sequence given in first source; the major cysteine protease of Trypanosoma cruzi; sequence similar to those of the papain family of cysteine proteases

Also Known As:

cruzain, Trypanosoma cruzi; cruzain protein, Trypanosoma cruzi

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Cysteine Proteases: 1964
        Cysteine Endopeptidases: 4
        Trypanosoma cruzi cruzain: 5
      - Endopeptidases: 633
        Cysteine Endopeptidases: 4
        Trypanosoma cruzi cruzain: 5
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Protozoan Proteins
    - Trypanosoma cruzi cruzain: 5

Experts

1.	Ferreira, Rafaela S: 2 articles (01/2020 - 10/2019)
2.	Andricopulo, Adriano D: 1 article (01/2020)
3.	Cruz, Fabio Cardoso: 1 article (01/2020)
4.	Dias, Luiz Carlos: 1 article (01/2020)
5.	Espinoza Chávez, Rocio Marisol: 1 article (01/2020)
6.	Ferreira, Leonardo L G: 1 article (01/2020)
7.	Krogh, Renata: 1 article (01/2020)
8.	Magalhães, Luma G: 1 article (01/2020)
9.	Oliva, Glaucius: 1 article (01/2020)
10.	Slafer, Brian W: 1 article (01/2020)

Related Diseases

1.	Infections 09/01/2000 - "The cysteine proteases of two trypanosomes, Trypanosoma cruzi (cruzain) and Trypanosoma brucei (rhodesain), have been targeted for a structure-based drug design program as mechanistic inhibitors that target these enzymes are effective in cell-based and animal models of trypanosomal infection. "
2.	Chagas Disease (American Trypanosomiasis) 01/01/2020 - "A virtual screening conducted with nearly 4 000 000 compounds from lead-like and fragment-like subsets enabled the identification of a small-molecule inhibitor (1) of the Trypanosoma cruzi cruzain enzyme, a validated drug target for Chagas disease. " 09/01/2016 - "The major cysteine protease of Trypanosoma cruzi, cruzain (CRZ), has been described as a therapeutic target for Chagas' disease, which affects millions of people worldwide. " 06/01/2000 - "The therapeutic potential of synthetic inhibitors to the major cysteine-proteinase from Trypanosoma cruzi (cruzain or cruzipain) was recently demonstrated in animal models of Chagas' disease. "
3.	Malaria 10/01/2019 - "To identify new chemical leads, we screened the 400 compounds of the Open Access Malaria Box against the cysteine proteases, cruzain (Trypanosoma cruzi), rhodesain (Trypanosoma brucei) and SmCB1 (Schistosoma mansoni), which are therapeutic targets for these diseases. "

Related Drugs and Biologics

1.	Cysteine Proteases (Cysteine Protease)
2.	Enzymes
3.	rhodesain
4.	cruzipain