N-(4-iodophenethyl)maleimide (IPEM)

structure given in first source; used for radiolabeling proteins

Also Known As:

IPEM; N-(4-iodophenethyl)maleimide, 125I-labeled; N-(p-(125I)-iodophenethyl)maleimide; N-(p-iodophenethyl)maleimide

Networked: 7 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jewell, Christopher M: 3 articles (02/2017 - 12/2015)
2.	Chiu, Yu-Chieh: 2 articles (02/2017 - 12/2015)
3.	Gammon, Joshua M: 2 articles (02/2017 - 12/2015)
4.	Tostanoski, Lisa H: 2 articles (02/2017 - 12/2015)
5.	Andorko, James I: 2 articles (01/2017 - 12/2015)
6.	Abrams, Ken: 1 article (09/2021)
7.	Balsa, Alejandro C: 1 article (09/2021)
8.	Combe, Bernard: 1 article (09/2021)
9.	Gottlieb, Alice B: 1 article (09/2021)
10.	James, David: 1 article (09/2021)

Related Diseases

1.	Psoriatic Arthritis 09/01/2021 - "Using a machine learning approach, the study investigated if specific baseline characteristics could predict which psoriatic arthritis (PsA) patients may gain additional benefit from a starting dose of secukinumab 300 mg over 150 mg. We also report results from individual patient efficacy meta-analysis (IPEM) in 2049 PsA patients from the FUTURE 2 to 5 studies to evaluate the efficacy of secukinumab 300 mg, 150 mg with and without loading regimen versus placebo at week 16 on achievement of several clinically relevant difficult-to-achieve (higher hurdle) endpoints. "
2.	Neoplasms (Cancer) 11/01/1991 - "A biodistribution study of the IPEM conjugate in tumor-bearing athymic nude mice showed lack of significant accumulation of radioiodine in the thyroid and stomach which was an indication of in vivo stability. " 02/13/2017 - "In mice, application of iPEM-coated MNs results in the codelivery of tumor antigen and CpG through the skin, expanding tumor-specific T cells during initial MN applications and resulting in larger memory recall responses during a subsequent booster MN application. " 12/14/2015 - "These immune-polyelectrolyte (iPEM) capsules offer a high signal density, selectively expand T cells in mice, and drive functional responses during tumor challenge. " 01/01/2017 - "In a common exogenous antigen melanoma model, iPEM vaccines slowed or stopped tumor growth more effectively than equivalent ad-mixed formulations. "
3.	Melanoma (Melanoma, Malignant) 01/01/2017 - "In a common exogenous antigen melanoma model, iPEM vaccines slowed or stopped tumor growth more effectively than equivalent ad-mixed formulations. "
4.	Infections 07/01/1989 - "In addition, most cases of IPEM appear to be herpes associated despite the absence of clinically apparent HSV infection."
5.	Carcinoma (Carcinomatosis) 04/01/2015 - "(125)I-IPEM-ZHER2:2395 bound specifically to HER2-expressing human ovarian carcinoma cells (SKOV-3 cell line). "

Related Drugs and Biologics

1.	secukinumab
2.	Vaccines
3.	Neoplasm Antigens (Tumor Antigens)
4.	Antigens
5.	Polyelectrolytes