Ro 24-4383
desacetylcefotaxime linked by a carbamate bond at the 3' position to ciprofloxacin; structure given in first source; RN from Toxlit
Also Known As:
Ro-24-4383
Networked: 1
relevant articles (0 outcomes,
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Bio-Agent Context: Research Results
Related Diseases
| 1. | Pneumonia (Pneumonitis)
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| 2. | Meningitis
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| 3. | Infections
01/01/1991
- " The protective effect of Ro 24-4383 was demonstrated when administered 8 h before infection with E. " 01/01/1991
- " Ro 24-4383, although inactive against the S.-pneumoniae-induced pneumonia following one administration of the agent, was highly active (ED50 = 1.5) when three treatments were given following infection. " 01/01/1991
- " The activities (ED50: mg/kg s.c.) of Ro 24-4383, cefotaxime and ciprofloxacin in systemic murine infections were: Escherichia coli 257, 1.4, less than 0.5, less than 0.2; Klebsiella pneumoniae A, 11, 30, 0.7; Enterobacter cloacae 5699, 3.2, 35, less than 0.2; Citrobacter freundii BS16, 3, 41, less than 0.5; Serratia marcescens SM, 35, greater than 100, 1.6; Pseudomonas aeruginosa 5712, 67, 100, 10; P. "
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