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integrin alphavbeta6

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adhesion receptor for fibronectin

Also Known As:

integrin alpha(v)beta(6)

Networked: 42 relevant articles (1 outcomes, 2 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Biological Factors: 930
- Antigens: 91909
  - Neoplasm Antigens: 1533
    - integrin alphavbeta6: 42
Amino Acids, Peptides, and Proteins
- Proteins: 58343
  - Membrane Proteins: 4073
    - Cell Surface Receptors: 547
      - Immunologic Receptors: 6
        Integrins: 2089
        integrin alphavbeta6: 42

Experts

1.	Niu, Jun: 5 articles (01/2010 - 02/2002)
2.	Marshall, John F: 5 articles (07/2009 - 06/2007)
3.	Sutcliffe, Julie L: 4 articles (07/2009 - 08/2007)
4.	Sheppard, Dean: 4 articles (04/2008 - 02/2002)
5.	Jackson, Terry: 4 articles (08/2007 - 02/2002)
6.	Chen, Rong: 3 articles (01/2010 - 05/2008)
7.	Hausner, Sven H: 3 articles (07/2009 - 08/2007)
8.	Thomas, Gareth J: 3 articles (07/2009 - 06/2007)
9.	Häkkinen, Lari: 3 articles (06/2009 - 05/2008)
10.	Thomas, G J: 3 articles (10/2005 - 06/2001)

Related Diseases

1.	Neoplasms (Cancer) 07/15/2009 - "Targeted in vivo imaging of integrin alphavbeta6 with an improved radiotracer and its relevance in a pancreatic tumor model." 07/01/2009 - "Integrin alphavbeta6 is not expressed in healthy adult epithelia but is upregulated during wound healing and in cancer. " 07/01/2009 - "Defining the role of integrin alphavbeta6 in cancer." 03/01/2009 - "Significant upregulation of the integrin alpha(v)beta(6) has been described as a prognostic indicator in several cancers, making it an attractive target for tumor imaging. " 05/01/2008 - "Integrin alphavbeta6 is generally not expressed in adult epithelia but is induced in wound healing, cancer, and certain fibrotic disorders. " Order ALL the reference details at left...
2.	Colonic Neoplasms (Colon Cancer) 08/08/2008 - "In this study, we investigated the apoptosis and its related signal pathways to integrin alphavbeta6 in colon cancer cells. " 08/08/2008 - "We confirmed that integrin alphavbeta6 acted as an important role in inhibiting apoptosis in colon cancer cells, and the signaling involved the mitochondrial pathway." 08/08/2008 - "Signaling and regulatory mechanisms of integrin alphavbeta6 on the apoptosis of colon cancer cells." 05/01/2008 - "Integrin alpha v beta 6 (alpha v beta 6) is correlated with colon cancer progression. " 05/01/2008 - "Integrin alpha v beta 6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver." Order ALL the reference details at left...
3.	Infection 04/01/2008 - "Immunohistochemical analysis showed integrin alphavbeta6 up-regulation in capillaries proximal to foci of CMV infection in lungs, salivary glands, uterine decidua, and injured chorionic villi of the placenta, demonstrating both its induction in endothelium and up-regulation in epithelium in vivo. " 07/01/2004 - "Thus, integrin alpha(v)beta(6) is an RGD-dependent receptor for CAV9 and may be important in natural CAV9 infections." 12/08/1997 - "Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells." 04/01/2008 - "Here, we report that CMV infection induces integrin alphavbeta6 expression in endothelial cells, leading to activation of TGF-beta1, signaling through its receptor ALK5, and phosphorylation of its intracellular effector Smad3. " 08/01/2007 - "In contrast, primary bovine thyroid cell cultures could be productively infected by viruses with replacement L(147)-->P, and this infection was inhibited by antibodies to alphavbeta6 and by an FMDV-derived RGD-containing peptide, suggesting that integrin alphavbeta6 may be used as a receptor for these mutants in the animal (porcine, guinea pig, and suckling mice) host. " Order ALL the reference details at left...
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 02/01/2010 - "Besides, we showed that integrin alphavbeta6 is universally (94.7%, 36/38) expressed in all major kinds of head and neck squamous cell carcinomas (HNSCC). " 05/01/2009 - "Dysplastic lesions had significantly lower expression of the epithelial-to-mesenchymal transition phenotype than the squamous cell carcinomas, and integrin-alpha v beta 6 membrane expression increased stepwise according to the histopathologic severity. " 06/01/2001 - "The integrin alphaVbeta6 is a fibronectin receptor, which is not detectable on normal epithelium but is neo-expressed in oral epithelial dysplasia and oral squamous-cell carcinoma (SCC), suggesting a role in promoting malignant behaviour and tumour progression. " 07/01/2001 - "The integrin alphavbeta6 is a fibronectin receptor whose expression is not detectable on normal oral epithelium but is increased significantly in healing and in oral epithelial dysplasia and oral squamous cell carcinoma, suggesting it may promote changes associated with tumor development. " 10/01/2005 - "The integrin alphavbeta6, a receptor for fibronectin, vitronectin, tenascin and TGF-beta latency-associated peptide (LAP), is not detectable on normal oral epithelium but is neo-expressed in oral squamous cell carcinomas (OSCC) and epithelial dysplasia. " Order ALL the reference details at left...
5.	Carcinoma (Carcinomatosis) 06/01/2007 - "Enhanced expression levels of integrin alphavbeta6 have been linked to more aggressive invasive carcinoma cell behavior and poorer clinical prognosis. " 10/01/2005 - "Using a colon carcinoma model of EMT, it was discovered that increased expression of the integrin alphavbeta6 is elicited as a consequence of the transition. " 07/01/2009 - "The epithelial cell-specific integrin alphavbeta6 represents an attractive target for directed therapy since it is generally not expressed on normal epithelium but is upregulated in numerous carcinomas, where it plays a role in tumor progression. " 06/01/2007 - "HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6." 01/01/2010 - "BACKGROUND: Integrin alphavbeta6 is up-regulated in a variety of human carcinomas and plays a crucial role in tumor invasion and metastasis. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	norcantharidin
3.	Transforming Growth Factor beta (TGF-beta)
4.	Transforming Growth Factor beta1 (TGF beta 1)
5.	Integrin alpha5beta1
6.	Matrix Metalloproteinase 9 (Gelatinase B)
7.	Collagen
8.	Clathrin
9.	Chymases (Chymase)
10.	Transforming Growth Factor beta3 (TGF beta 3)

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