|1.||Marshall, John F: 6 articles (09/2010 - 06/2007)|
|2.||Niu, Jun: 5 articles (01/2010 - 02/2002)|
|3.||Thomas, Gareth J: 4 articles (09/2010 - 06/2007)|
|4.||Sutcliffe, Julie L: 4 articles (07/2009 - 08/2007)|
|5.||Sheppard, Dean: 4 articles (04/2008 - 02/2002)|
|6.||Jackson, Terry: 4 articles (08/2007 - 02/2002)|
|7.||Hart, Ian R: 3 articles (09/2010 - 06/2007)|
|8.||Chen, Rong: 3 articles (01/2010 - 05/2008)|
|9.||Hausner, Sven H: 3 articles (07/2009 - 08/2007)|
|10.||Häkkinen, Lari: 3 articles (06/2009 - 05/2008)|
07/15/2009 - "Targeted in vivo imaging of integrin alphavbeta6 with an improved radiotracer and its relevance in a pancreatic tumor model."
09/01/2010 - "The integrin alphavbeta6 is expressed only on epithelia and then usually only during processes of tissue remodelling including cancer, where its high expression correlates with reduced survival. "
07/01/2009 - "Integrin alphavbeta6 is not expressed in healthy adult epithelia but is upregulated during wound healing and in cancer. "
07/01/2009 - "Defining the role of integrin alphavbeta6 in cancer."
03/01/2009 - "Significant upregulation of the integrin alpha(v)beta(6) has been described as a prognostic indicator in several cancers, making it an attractive target for tumor imaging. "
|2.||Colonic Neoplasms (Colon Cancer)
08/08/2008 - "In this study, we investigated the apoptosis and its related signal pathways to integrin alphavbeta6 in colon cancer cells. "
08/08/2008 - "We confirmed that integrin alphavbeta6 acted as an important role in inhibiting apoptosis in colon cancer cells, and the signaling involved the mitochondrial pathway."
08/08/2008 - "Signaling and regulatory mechanisms of integrin alphavbeta6 on the apoptosis of colon cancer cells."
05/01/2008 - "Integrin alpha v beta 6 (alpha v beta 6) is correlated with colon cancer progression. "
05/01/2008 - "Integrin alpha v beta 6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver."
04/01/2008 - "Immunohistochemical analysis showed integrin alphavbeta6 up-regulation in capillaries proximal to foci of CMV infection in lungs, salivary glands, uterine decidua, and injured chorionic villi of the placenta, demonstrating both its induction in endothelium and up-regulation in epithelium in vivo. "
07/01/2004 - "Thus, integrin alpha(v)beta(6) is an RGD-dependent receptor for CAV9 and may be important in natural CAV9 infections."
12/08/1997 - "Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells."
04/01/2008 - "Here, we report that CMV infection induces integrin alphavbeta6 expression in endothelial cells, leading to activation of TGF-beta1, signaling through its receptor ALK5, and phosphorylation of its intracellular effector Smad3. "
08/01/2007 - "In contrast, primary bovine thyroid cell cultures could be productively infected by viruses with replacement L(147)-->P, and this infection was inhibited by antibodies to alphavbeta6 and by an FMDV-derived RGD-containing peptide, suggesting that integrin alphavbeta6 may be used as a receptor for these mutants in the animal (porcine, guinea pig, and suckling mice) host. "
07/01/2001 - "The integrin alphavbeta6 is restricted to epithelial cells and is dramatically induced in response to injury and inflammation. "
05/01/1996 - "These results suggest that the epithelial integrin alpha v beta 6 participates in the modulation of epithelial inflammation. "
04/01/2008 - "TGF-beta1 is activated by integrin alphavbeta6, which is strongly induced in the epithelium by injury and inflammation but has not previously been found in endothelial cells. "
08/15/2007 - "Expression of the epithelial-specific integrin alphavbeta6 is low or undetectable in most adult tissues but may be increased during wound healing and inflammation and is up-regulated dramatically by many different carcinomas, making alphavbeta6 a promising target for the in vivo detection of cancer using noninvasive imaging. "
02/05/1999 - "We show that TGF beta 1 LAP is a ligand for the integrin alpha v beta 6 and that alpha v beta 6-expressing cells induce spatially restricted activation of TGF beta 1. This finding explains why mice lacking this integrin develop exaggerated inflammation and, as we show, are protected from pulmonary fibrosis. "
|5.||Squamous Cell Carcinoma (Epidermoid Carcinoma)
02/01/2010 - "Besides, we showed that integrin alphavbeta6 is universally (94.7%, 36/38) expressed in all major kinds of head and neck squamous cell carcinomas (HNSCC). "
05/01/2009 - "Dysplastic lesions had significantly lower expression of the epithelial-to-mesenchymal transition phenotype than the squamous cell carcinomas, and integrin-alpha v beta 6 membrane expression increased stepwise according to the histopathologic severity. "
06/01/2001 - "The integrin alphaVbeta6 is a fibronectin receptor, which is not detectable on normal epithelium but is neo-expressed in oral epithelial dysplasia and oral squamous-cell carcinoma (SCC), suggesting a role in promoting malignant behaviour and tumour progression. "
07/01/2001 - "The integrin alphavbeta6 is a fibronectin receptor whose expression is not detectable on normal oral epithelium but is increased significantly in healing and in oral epithelial dysplasia and oral squamous cell carcinoma, suggesting it may promote changes associated with tumor development. "
10/01/2005 - "The integrin alphavbeta6, a receptor for fibronectin, vitronectin, tenascin and TGF-beta latency-associated peptide (LAP), is not detectable on normal oral epithelium but is neo-expressed in oral squamous cell carcinomas (OSCC) and epithelial dysplasia. "
|3.||Transforming Growth Factor beta (TGF-beta)
|4.||Transforming Growth Factor beta1 (TGF beta 1)
|6.||Matrix Metalloproteinase 9 (Gelatinase B)
|10.||Transforming Growth Factor beta3 (TGF beta 3)