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lysyl-aspartyl-glutamyl-leucine

retains type II surface membrane proteins in the endoplasmic reticulum; RN refers to all (L)-isomer
Also Known As:
KDEL sequence; Lys-Asp-Glu-Leu
Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Ko, Kisung: 3 articles (10/2021 - 06/2004)
2. Lee, Young Koung: 2 articles (10/2021 - 01/2018)
3. Song, Ilchan: 2 articles (10/2021 - 01/2018)
4. Kim, Dae Heon: 1 article (10/2021)
5. Kim, Do Sun: 1 article (10/2021)
6. Kim, Jin Wook: 1 article (10/2021)
7. Kim, Mi Kyung: 1 article (10/2021)
8. Kim, Moon-Soo: 1 article (10/2021)
9. Ko, Kinarm: 1 article (10/2021)
10. Lee, Hae Kyung: 1 article (10/2021)

Related Diseases

1. Neoplasms (Cancer)
11/22/2022 - "CALR mutations occur in patients with myeloproliferative neoplasms (MPNs), and the ER retention of CALR mutants (CALR MUT) is reduced due to a lacking KDEL sequence. "
12/17/2014 - "We identified two distinct sites, one within the catalytic domain and one close to the C-terminal KDEL sequence of Ec1-ETA″, simultaneous PEGylation of which resulted in up to 1000-fold lower cytotoxicity in EpCAM-positive tumor cells. "
10/01/2010 - "It has been reported that the heparanase epitope can elicit a CTL-mediated anti-tumor response; however, the potential of the heparanase epitope modified by an endoplasmic reticulum (ER) retrieval signal, a C-terminal Lys-Asp-Glu-Leu sequence, is still unknown. "
11/01/2012 - "The purpose of this study was to target ovarian cancer cells by coupling paclitaxel (Tx)-loaded nanoparticles (NPs-Tx) to antibodies against KDEL sequence, able to recognize GRP94 and GRP78 that are located at cell surface in cancer cells whereas they are in the endoplasmic reticulum in healthy cells. "
11/01/2018 - "Furthermore, quercetin increased the gene expressions of TNFRSF10D (Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain), TP53INP1 (tumor protein p53 inducible nuclear protein 1), and JUNB (jun B proto-oncogene) but decreased the gene expression of VEGFB (vascular endothelial growth factor B), CDK10 (cyclin-dependent kinase 10), and KDELC2 (KDEL [Lys-Asp-Glu-Leu] containing 2) that are associated with apoptosis pathways. "
2. Ovarian Neoplasms (Ovarian Cancer)
3. Colorectal Neoplasms (Colorectal Cancer)
4. Rabies (Hydrophobia)
5. Neurodegenerative Diseases (Neurodegenerative Disease)

Related Drugs and Biologics

1. Paclitaxel (Taxol)
2. Antibodies
3. Endoplasmic Reticulum Chaperone BiP
4. glucose-regulated proteins
5. lysyl-aspartyl-glutamyl-leucine
6. Vascular Endothelial Growth Factor B
7. Cyclin-Dependent Kinases (cdk Proteins)
8. Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
9. Quercetin
10. Proteins (Proteins, Gene)