kamikihi-to (KKT)

Chinese traditional medicine; enhances both the Bmax & Vmax for QNB binding & CAT activity in aged rats, respectively; consists of Astragalus, Ginseng, Atractylodes, Hoelen, Polygala, Jujube, Longan, Zizyphus, Angelica, Licorice, Ginger, Saussurea, Bupleurum and Gardenia

Also Known As:

Networked: 33 relevant articles (16 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tohda, Chihiro: 4 articles (01/2019 - 12/2011)
2.	Shimada, Yutaka: 3 articles (01/2019 - 01/2011)
3.	Watari, Hidetoshi: 3 articles (01/2019 - 01/2014)
4.	Ishikawa, Hideki: 2 articles (07/2022 - 01/2021)
5.	Ito, Masanori: 2 articles (07/2022 - 01/2021)
6.	Ogawa-Ochiai, Keiko: 2 articles (07/2022 - 01/2021)
7.	Okajima, Masaki: 2 articles (07/2022 - 01/2021)
8.	Ikemoto, Hideshi: 2 articles (03/2022 - 08/2021)
9.	Inoue, Tatsuki: 2 articles (03/2022 - 08/2021)
10.	Sunagawa, Masataka: 2 articles (03/2022 - 08/2021)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 11/27/2023 - "Recently, the efficacy of KKT against Alzheimer's disease (AD) has been demonstrated in clinical and non-clinical studies. " 01/01/2019 - "We previously reported that the administration of traditional Japanese medicines, kihito (Gui-Pi-Tang in Chinese) and kamikihito (Jia-Wei-Gui-Pi-Tang in Chinese), to Alzheimer's disease (AD) model mice improved memory impairment. " 05/01/2015 - "[Kamikihito improves memory dysfunction in Alzheimer's disease]." 01/01/2014 - "New Treatment for Alzheimer's Disease, Kamikihito, Reverses Amyloid-β-Induced Progression of Tau Phosphorylation and Axonal Atrophy." 01/01/2014 - "We previously reported that kamikihito (KKT), a traditional Japanese medicine, improved memory impairment and reversed the degeneration of axons in the 5XFAD mouse model of Alzheimer's disease (AD). "
2.	Communicable Diseases (Infectious Diseases) 07/15/2022 - "Although the biological properties and safety of the representative Kampo, Hochuekkito (HET), and Kakkonto (KKT) have been confirmed in various animal model experiments and clinical studies, and in a few human studies to induce biological effects on various infectious diseases without significant toxicity, it is unclear whether HET and KKT are safe and effective for COVID-19 prevention. " 01/01/2021 - "Although the biological properties and safety of the representative Kampo compounds, hochuekkito (HET) and kakkonto (KKT), have been confirmed in various animal model experiments, clinical studies, and a few human studies to induce biological effects on various infectious diseases without significant toxicity, it is unclear whether HET and KKT are safe and effective for COVID-19 prevention. "
3.	COVID-19 07/15/2022 - "In conclusion, HET and KKT may have prevented the onset or worsening of COVID-19, which could be clinically used. " 01/01/2021 - "HET and KKT may prevent the onset or worsening of COVID-19 through their immunomodulatory effects." 07/15/2022 - "Although the biological properties and safety of the representative Kampo, Hochuekkito (HET), and Kakkonto (KKT) have been confirmed in various animal model experiments and clinical studies, and in a few human studies to induce biological effects on various infectious diseases without significant toxicity, it is unclear whether HET and KKT are safe and effective for COVID-19 prevention. " 01/01/2021 - "Although the biological properties and safety of the representative Kampo compounds, hochuekkito (HET) and kakkonto (KKT), have been confirmed in various animal model experiments, clinical studies, and a few human studies to induce biological effects on various infectious diseases without significant toxicity, it is unclear whether HET and KKT are safe and effective for COVID-19 prevention. "
4.	Pain (Aches) 04/01/2022 - "Following KKT, he demonstrated improvement in pain, function, quality of life, sleep, and trunk range of motion with no adverse events." 06/15/2011 - "The KKT intervention is in clinical use for spinal ailment pain reduction. " 09/01/2007 - "Although we await randomized placebo controlled trials and additional results from ongoing mechanistic studies, initial results show that KKT is potentially an effective treatment for chronic neck pain and may contribute to the reduction of pain relieving medication." 09/01/2007 - "To demonstrate initial results using Khan Kinetic Treatment (KKT) as a chronic neck pain treatment and to present pain control mechanistic theory on which the treatment is based. "
5.	Pharyngitis (Sore Throat) 09/01/2019 - "We investigated the efficacy of KKT on sore throat associated with acute URTI. " 09/01/2019 - "Conclusion KKT did not significantly relieve sore throat associated with acute URTI compared with placebo." 09/01/2019 - "The proportion of patients with a moderate or greater impact of their sore throat on their daily life was also not significantly different between the groups (KKT 22.9% vs. placebo 40.0%; p=0.20). " 09/01/2019 - "The difference in the mean change of sore throat score according to VAS within 10 minutes between the two groups was not statistically significant (KKT 14.40 vs. placebo 17.00; p=0.39). " 09/01/2019 - "The primary outcome was the change in sore throat score on VAS 10 minutes after KKT administration. "

Related Drugs and Biologics

1.	kamikihi-to (KKT)
2.	kakkon-to
3.	bu-zhong-yi-qi-tang
4.	Lipopolysaccharides
5.	Inosine Triphosphate (ITP)
6.	Ascorbic Acid (Vitamin C)
7.	Amyloid (Amyloid Fibrils)
8.	Protein Phosphatase 2 (Protein Phosphatase 2A)
9.	Cholinergic Agents (Cholinergics)
10.	Cytokines

Related Therapies and Procedures

1.	Kampo Medicine (Kampo)
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Therapeutics
4.	East Asian Traditional Medicine (Oriental Medicine)
5.	General Anesthesia