sinapinic acid

a matrix for matrix-assisted laser desorption technique for protein MW determination; a constituent of propolis

Also Known As:

(E)-sinapic acid; 2-propenoic acid, 3-(4-hydroxy-3,5-dimethoxyphenyl)-; 3,5-dimethoxy-4-hydroxycinnamic acid; 4-hydroxy-3,5-dimethoxycinnamic acid; cinnamic acid, 4-hydroxy-3,5-dimethoxy-, (E)-; sinapic acid; sinapic acid, (E)-; synapitic acid; trans-sinapic acid; trans-sinapinic acid

Networked: 112 relevant articles (22 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Cinnamates: 48
      - Coumaric Acids: 128
        sinapinic acid: 112

Experts

1.	Ahmad, Ajaz: 10 articles (06/2022 - 11/2016)
2.	Raish, Mohammad: 10 articles (06/2022 - 11/2016)
3.	Ansari, Mushtaq Ahmad: 9 articles (06/2022 - 11/2016)
4.	Al-Jenoobi, Fahad I: 7 articles (06/2022 - 12/2018)
5.	Alkharfy, Khalid M: 7 articles (06/2022 - 04/2017)
6.	Ahad, Abdul: 6 articles (06/2022 - 12/2018)
7.	Bin Jardan, Yousef A: 6 articles (06/2022 - 01/2020)
8.	Shahid, Mudassar: 5 articles (06/2022 - 01/2021)
9.	Song, Jia-Le: 4 articles (11/2022 - 01/2020)
10.	Zeng, Zhen: 3 articles (11/2022 - 01/2020)

Related Diseases

1.	Inflammation (Inflammations) 06/28/2022 - "Conclusion: Sinapic acid significantly ameliorates AA induced UC in rats by suppressing inflammation, oxidative stress, and apoptosis in colonic tissues which exhibits its potential for the management of UC." 12/31/2022 - "Dietary Sinapic Acid Alleviates Adiposity and Inflammation in Diet-Induced Obese Mice." 01/01/2021 - "Sinapic acid (SA) was reported to protect against inflammation in various types of diseases. " 03/01/2018 - "In general, this paper elucidates that sinapic acid inhibits the IL-1β-induced inflammation via MAPK pathways and may be a good agent for the treatment of OA." 03/01/2018 - "Sinapic Acid Inhibits the IL-1β-Induced Inflammation via MAPK Downregulation in Rat Chondrocytes."
2.	Fibrosis (Cirrhosis) 05/01/2013 - "Additionally, the expression of hepatic fibrosis-related factors such as α-smooth muscle actin and transforming growth factor-β1 (TGF-β1), were reduced in rats treated with sinapic acid. " 05/01/2013 - "This suggests that sinapic acid is a potentially useful agent for the protection against liver fibrosis and cirrhosis." 12/01/2018 - "Sinapic acid ameliorates bleomycin-induced lung fibrosis in rats." 12/01/2018 - "We explore the possible discourse of sinapic acid (SA) against the prevention of bleomycin (BLM)-instigated lung fibrosis in rats through modulation of Nrf2/HO-1 and NF-κB signaling pathways. " 05/01/2013 - "Effect of sinapic acid against dimethylnitrosamine-induced hepatic fibrosis in rats."
3.	Hyperglycemia 12/11/2013 - "Sinapic acid dose-dependently reduced the hyperglycemia of STZ-diabetic rats (9.8 ± 1.8%, 11.6 ± 0.7%, and 19.4 ± 3.2% at 5 mg/kg, 10 mg/kg, and 25 mg/kg, respectively). " 12/11/2013 - "Our results suggest that sinapic acid ameliorates hyperglycemia through PLC-PKC signals to enhance the glucose utilization in diabetic rats. " 01/01/2022 - "Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy via improvement of hyperglycemia, hyperlipidemia, inflammation, oxidative stress, and apoptosis. " 10/01/2021 - "Combined treatment of sinapic acid and ellagic acid attenuates hyperglycemia in streptozotocin-induced diabetic rats."
4.	Cardiotoxicity 01/01/2023 - "In conclusion, our results suggest that sinapic acid exhibited a protective effect against the cardiotoxicity induced by cisplatin. " 01/01/2020 - "Sinapic Acid Ameliorates Oxidative Stress, Inflammation, and Apoptosis in Acute Doxorubicin-Induced Cardiotoxicity via the NF-κB-Mediated Pathway." 01/01/2023 - "Sinapic Acid Attenuated Cisplatin-Induced Cardiotoxicity by Inhibiting Oxidative Stress and İnflammation with GPX4-Mediated NF-kB Modulation." 01/01/2023 - "The anti oxidant, anti-inflammatory, and peroxynitrite-scavenging properties of sinapic acid could provide protection against the cardiotoxicity caused by cisplatin. "
5.	Ischemia 08/01/2011 - "Effects of sinapic Acid of 4 vessel occlusion model-induced ischemia and cognitive impairments in the rat." 12/10/2021 - "and Brassica oleracea Var.), which was rich in scutellarin and sinapic acid, after the ischemia, significantly improved ischemia-induced decline in memory function when compared with that shown in gerbils treated with vehicle after the ischemia. " 01/24/2015 - "The present study was designed to evaluate antioxidant and cardioprotective potential of sinapic acid (SA) against ischemia/reperfusion (I/R) injury. " 01/01/2020 - "Finally, ROS production was measured with DHE 10 min after ischemia-reperfusion (IR) on isolated heart, treated or not with sinapine, sinapic acid or with a known synthetic mitochondrion-targeted antioxidant (mitoTempo). "

Related Drugs and Biologics

1.	Antioxidants
2.	Streptozocin (Streptozotocin)
3.	Cytokines
4.	phenolic acid
5.	Lipids
6.	Enzymes
7.	Isoproterenol (Isoprenaline)
8.	Lipoproteins (Lipoprotein)
9.	Coumaric Acids
10.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Immunomodulation
2.	Therapeutics
3.	Ligation
4.	Decompression