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2,5- dimethyl- 3,6- diaziridinyl- 1,4- benzoquinone

structure given in first source

Also Known As:

MeDZQ

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azirines
    - Aziridines: 14
      - 2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone: 5
Organic Chemicals: 133
- Quinones: 434
  - Benzoquinones: 25
    - 2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone: 5

Experts

1.	Alksne, Milda: 1 article (01/2017)
2.	Bartuskiene, Violeta: 1 article (01/2017)
3.	Bukelskiene, Virginija: 1 article (01/2017)
4.	Burinskij, Jaroslav: 1 article (01/2017)
5.	Cenas, Narimantas: 1 article (01/2017)
6.	Jarasiene-Burinskaja, Rasa: 1 article (01/2017)
7.	Voisniene, Violeta: 1 article (01/2017)
8.	Butler, John: 1 article (09/2003)
9.	Cummings, Jeffrey: 1 article (09/2003)
10.	Langdon, Simon: 1 article (09/2003)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 09/01/2003 - "The antitumour efficacy of RH1 and MeDZQ has been studied in 4 human xenografts (3 non-small cell lung cancer and 1 colon cancer), and compared to the level of constitutive DT-Diaphorase activity measured by the DCPIP assay. "
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/01/2003 - "The antitumour efficacy of RH1 and MeDZQ has been studied in 4 human xenografts (3 non-small cell lung cancer and 1 colon cancer), and compared to the level of constitutive DT-Diaphorase activity measured by the DCPIP assay. "
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/2017 - "The aim of this study was to partly fill this gap by characterizing the mode of cytotoxicity of 2,5-diaziridinyl-3,6-dimethyl-1,4-benzoquinone (MeDZQ) in malignant mouse hepatoma cells (MH-22A) with regard to the expression and activation of main molecules in MAPK cell signaling pathway. " 01/01/2017 - "Study of the cytotoxic effects of 2,5-diaziridinyl-3,6-dimethyl-1,4-benzoquinone (MeDZQ) in mouse hepatoma cells."
4.	Neoplasms (Cancer) 06/15/1994 - "coli DTD can be observed, compounds such as 2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone and streptonigrin are still excellent substrates for the human enzyme and may be useful in the therapy of tumors high in DTD activity. "
5.	Lung Neoplasms (Lung Cancer) 09/01/1995 - "The cytotoxicity of MeDZQ and MC was examined in a panel of human breast and lung cancer cell lines. "

Related Drugs and Biologics

1.	NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)
2.	Streptonigrin (Nigrin)
3.	Enzymes
4.	diaziquone (AZQ)

Related Therapies and Procedures

1.	Therapeutics