HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

fertilin

fertilin is a sperm surface protein involved in sperm-egg fusion; consists of two subunits, fertilin alpha and beta, both of which belong to the metalloprotease-disintegrin protein family; RefSeq NM_172126 (Adam1a, mouse); NM_172125 (Adam1b, mouse); NM_009618 (Adam2, mouse); NM_020078 (Adam1a, rat); NM_020077 (Adam2, rat); NM_001464 (ADAM2, human)

Also Known As:

ADAM 1 protein; ADAM 2 protein; ADAM2 protein, human; Adam1a protein, mouse; Adam1a protein, rat; Adam1b protein, mouse; Adam2 protein, mouse; Adam2 protein, rat; PH 30 fusion protein; PH-30 alpha; PH-30 beta; PH-30 beta protein, mouse; PH-30 fusion protein; PH-30 protein; PH-30b protein, human; a disintegrin and metallopeptidase domain 1a protein, rat; a disintegrin and metalloprotease domain 2 protein, mouse; a disintegrin and metalloprotease domain 2 protein, rat; a disintegrin and metalloproteinase domain 1a protein, mouse; a disintegrin and metalloproteinase domain 1b protein, mouse; a disintegrin and metalloproteinase domain 2 protein, human; fertilin alpha; fertilin beta; fertilin beta protein, human; fertilin beta protein, mouse; fertilin beta protein, rat

Networked: 8 relevant articles (0 outcomes, 1 trials/studies) for this Bio-Agent, Comments

Bio-Agent Context: Research Results

Experts

1.	Yamaguchi, Ryou: 1 article (10/2002)
2.	Yamagata, Kazuo: 1 article (10/2002)
3.	Okabe, Masaru: 1 article (10/2002)
4.	Nakanishi, Tomoko: 1 article (10/2002)
5.	Moss, Stuart B: 1 article (10/2002)
6.	Ikawa, Masahito: 1 article (10/2002)

Related Diseases

1.	Infertility (Sterility) 01/01/1996 - "In a pilot fertility trial, immunization of male guinea pigs with purified guinea pig fertilin resulted in complete infertility. " 10/15/2002 - "The cause of the sterility initially was considered to be impaired abilities in sperm/zona pellucida (ZP) and sperm/egg plasma membrane (EPM) binding, and in the ascension of sperm to the oviduct, phenotypes similar to those seen in sperm from fertilin beta-deficient animals. " 10/12/1999 - "These findings correlate with the observation that fertilin beta "knockout" sperm traverse the uterus but do not progress into the oviduct, contributing to the infertility of fertilin beta(-/-) male mice. " 10/01/1997 - "These results show that in the rabbit, high levels of circulating sperm-reactive anti-fertilin antibodies and the presence of vaginal IgG does not ensure infertility." Order ALL the reference details at left...
2.	Herpes Zoster 02/01/1999 - "Micromolar quantities of hexapeptides or a 28 aa residue peptide, all corresponding to fertilin beta disintegrin domain, competitively inhibited the binding of zona-free baboon eggs by baboon sperm in vitro. " 09/18/1998 - "Fertilin could also have a direct role in sperm-zona binding or oviduct migration; alternatively, the effects on these functions could result from the absence of fertilin activity during spermatogenesis." 06/01/1997 - "The binding of human spermatozoa to, and penetration of, zona-free hamster oocytes were significantly inhibited in the presence of (i) a 28-residue peptide corresponding to part of the disintegrin-like domain of monkey fertilin beta, or (ii) a hexapeptide containing the ECD motif found in the disintegrin-like domain of monkey and human fertilin beta, or (iii) a hexapeptide containing an RGD motif, implicated in integrin recognition. " 05/01/1999 - "We evaluated whether fertilin beta plays a role in human fertilization by studying the effects of a linear octapeptide containing the FEE sequence, SFEECDLP, and a scrambled octapeptide with the same amino acids, SFPCEDEL, on the incorporation of human spermatozoa by human zona-free eggs. " 02/01/1999 - "Fertilin beta peptides inhibit sperm binding to zona-free eggs in a homologous baboon in vitro fertilization system." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Peptides
2.	Immunoglobulin G (IgG)
3.	Antibodies
4.	Amino Acids

blog comments powered by Disqus

TREATMENT OPTIONS
for Infertility,
Ranking and Evidence

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. Analytic charts allow you and your physicians to see at a glance the treatment options—including new, promising, off-label and experimental.

Free Updates for 1 Year
All 235 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Evidence References
Sample PDF Report on Psoriasis >>

Price:

$8.50 USD & Delivery via PDF download
updates for 1 year

Research Interface PRO

Rapidly retrieve clinical outcome summaries for all evidence of drug efficacy against any disease in seconds. Click "Charts" to view graphs of relative efficacy of all drugs against any known disease. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time. Save hours of search and analysis time:

Two-clicks from Disease to Drug to Evidence: Drill down to full abstract
Enable Experts: Quickly identify key researchers and their publications
Enable FDA Link Generic: Two-clicks to FDA Products/Patents/Generics
Enable Export: All outcome statements and scores exportable to Excel/TSV for automated meta-analysis
Research Network: Explore drug and disease relationships visually
Enable Mobile Interface: Access from your cellphone, iPhone or PDA

Price:

$45.00 USD access via web interface
1 year subscription

Request Bulk Institution License Details >>