KT 5823

indolocarbazole; activates human neutrophils & fails to inhibit cGMP-dependent protein kinase phosphorylation of vimentin

Also Known As:

9-methoxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11-epxoy-1H,8H,11H-2,7b-11a-triazadibenzo(a,g)cycloocta(cde)-trinden-1-one; KT-5823; KT5823; 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9R-(9alpha,10beta,12alpha))-

Networked: 43 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Carbazoles: 32
        KT 5823: 43
  - 3-Ring Heterocyclic Compounds
    - Carbazoles: 32
      - KT 5823: 43

Experts

1.	Zhang, Li-Min: 3 articles (11/2020 - 07/2013)
2.	Etgen, Anne M: 3 articles (12/2019 - 01/2004)
3.	González-Flores, Oscar: 3 articles (12/2019 - 01/2004)
4.	García-Juárez, Marcos: 2 articles (12/2019 - 02/2012)
5.	Gómora-Arrati, Porfirio: 2 articles (12/2019 - 02/2012)
6.	Lima-Hernández, Francisco J: 2 articles (12/2019 - 02/2012)
7.	Niu, Chun-Yu: 2 articles (01/2016 - 07/2013)
8.	Zhang, Yu-Ping: 2 articles (01/2016 - 07/2013)
9.	Zhao, Zi-Gang: 2 articles (01/2016 - 07/2013)
10.	Baracat, Marcela M: 2 articles (11/2014 - 04/2013)

Related Diseases

1.	Wounds and Injuries (Trauma) 11/01/2020 - "Also, the following variables were measured: 1) neuronal pyroptosis and apoptosis 24 h post-trauma, 2) the roles of PKG-ERK1/2 signaling pathways with the use of the protein kinase G (PKG) specific inhibitor, KT5823. " 11/01/2020 - "CORM-3-treated rats displayed significant ameliorated depression- and anxiety-like behaviors, improved cerebral blood flow, and fractional anisotropy (FA), showed less neuronal pyroptosis and apoptosis in the amygdala, and upregulated the phosphorylation of Vasodilator-stimulated phosphoprotein (VASP) and ERK1/2. However, CORM-3 neuroprotective effects against trauma were only partially reversed by KT5823. "
2.	Inflammation (Inflammations) 12/01/2021 - "Inhibition of the cGMP-PKG pathway using inhibitor KT5823 relieved STEAP4 silencing-mediated suppression of cell proliferation and inflammation in LPS-stimulated cells. "
3.	Hypoxia (Hypoxemia) 01/22/2010 - "Slices treated with 8-Br-cGMP did not switch to the fictive gasp-like pattern following exposure to hypoxia whereas slices treated with KT5823 did display fictive gasping. " 04/01/2000 - "Furthermore, APIII depressed hypoxia-evoked elevations of intracellular Ca(2+), an effect that was also reversed by OA and KT-5823. " 01/01/2017 - "In H9c2 cardiac myoblasts, hypoxia-reoxygenation-mediated mitochondrial ROS generation was diminished with BAY 60-2770 treatment, but was recovered by pretreatment with KT-5823. " 12/01/2007 - "Inhibition of hypoxia-evoked Ca(2+) responses by SNAP is mediated via a cGMP/protein kinase G (PKG)-dependent mechanism in normal type I cells that is sensitive to the PKG inhibitor KT-5823, but following CH, inhibitory responses are minimally sensitive to PKG inhibition. " 10/01/2009 - "In cultured cardiomyocytes of neonatal rats, either sGC stimulator BAY 41-2272 or cGMP analog 8-bromo-cGMP decreased the hypoxia (1% O(2)/5% CO(2))-induced HIF-1alpha expression, whereas the inhibition of protein kinase G by KT-5823 reversed the effect of BAY 41-2272 on the expression under hypoxic conditions. "
4.	Lordosis 11/16/2001 - "Present studies show that KT5823 attenuates lordosis in a dose-dependent manner when infused bilaterally into the ventromedial hypothalamus. " 02/01/1999 - "KT5823 significantly decreased lordosis behaviour. " 01/01/2004 - "In Experiment 2, i.c.v. infusion of the protein kinase G inhibitor KT5823 significantly inhibited the lordosis behavior induced by all three progestins at 2 h. " 11/01/2023 - "Results showed that injections of either L-NAME or KT5823 significantly reduced the lordosis induced by apelin at 120 and 240 min. " 02/01/2012 - "Intracerebroventricular infusion of the PKG inhibitor (KT5823) 30 min before leptin infusion, also significantly inhibited the lordosis behavior induced by leptin at 1 and 2h after hormone administration. "
5.	Breast Neoplasms (Breast Cancer) 03/01/2011 - "Moreover, KT5823 accumulates hypoglycosylated NIS, and this effect is much more evident in breast cancer cells than thyroid cells. " 03/01/2011 - "Taken together, KT5823 will serve as a valuable pharmacological reagent to uncover mechanisms underlying differential NIS regulation between thyroid and breast cancer cells at multiple levels." 03/01/2011 - "KT5823 differentially modulates sodium iodide symporter expression, activity, and glycosylation between thyroid and breast cancer cells." 03/01/2011 - "In this study, we found that KT5823 does not increase but decreases iodide uptake within 0.5 h of treatment in trans-retinoic acid and hydrocortisone-treated MCF-7 breast cancer cells. "

Related Drugs and Biologics

1.	Neuroprotective Agents
2.	vasodilator-stimulated phosphoprotein
3.	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)
4.	N- (2- (4- bromocinnamylamino)ethyl)- 5- isoquinolinesulfonamide (h89)
5.	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
6.	protein kinase modulator
7.	Calcium-Calmodulin-Dependent Protein Kinase Type 2
8.	Protein Kinase C
9.	Tretinoin (Retinoic Acid)
10.	Iodides

Related Therapies and Procedures

1.	Intraventricular Infusions
2.	Vagus Nerve Stimulation
3.	Intradermal Injections
4.	Injections