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KT 5823

indolocarbazole; activates human neutrophils & fails to inhibit cGMP-dependent protein kinase phosphorylation of vimentin
Also Known As:
9-methoxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11-epxoy-1H,8H,11H-2,7b-11a-triazadibenzo(a,g)cycloocta(cde)-trinden-1-one; KT-5823; KT5823; 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9R-(9alpha,10beta,12alpha))-
Networked: 29 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Staurengo-Ferrari, Larissa: 2 articles (11/2014 - 04/2013)
2. Silva, Jean J: 2 articles (11/2014 - 04/2013)
3. da França, Luiz G: 2 articles (11/2014 - 04/2013)
4. Baracat, Marcela M: 2 articles (11/2014 - 04/2013)
5. Casagrande, Rubia: 2 articles (11/2014 - 04/2013)
6. Mizokami, Sandra S: 2 articles (11/2014 - 04/2013)
7. Georgetti, Sandra R: 2 articles (11/2014 - 04/2013)
8. Verri, Waldiceu A: 2 articles (11/2014 - 04/2013)
9. Pavanelli, Wander R: 2 articles (11/2014 - 04/2013)
10. González-Flores, Oscar: 2 articles (02/2012 - 01/2004)

Related Diseases

1. Anoxia (Hypoxia)
2. Lordosis
3. Breast Neoplasms (Breast Cancer)
4. Hyperalgesia
02/01/1996 - "In addition, KT5823 (1 nmol) or Rp-8-bromoguanosine-3':5'-cyclic monophosphothioate (Rp-8-Br-cGMPS; 1 nmol), an inhibitor of cyclic GMP-dependent protein kinase, also significantly suppressed BK-induced hyperalgesia. "
08/11/2010 - "Blockade of BNP signaling by BNP antibodies or cGMP-dependent protein kinase (PKG) inhibitor KT5823 [(9S,10R,12R)-2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester] impaired the recovery from CFA-induced thermal hyperalgesia. "
12/03/1999 - "Spinal PKA, but not PKG, is likely involved in Chung tactile allodynia, since H89 (a PKA inhibitor) showed anti-allodynic activity, while KT5823 (a PKG inhibitor) had only a minor effect. "
04/01/2013 - "The inhibitory effect of complex I in the carrageenin-induced hyperalgesia, MPO activity and formalin was prevented by the treatment with ODQ, KT5823 and glybenclamide, indicating that complex I inhibits inflammatory hyperalgesia by activating the cGMP/PKG/ATP-sensitive potassium channel signaling pathway. "
06/01/1997 - "Infusion of a G-protein inhibitor (GDP-beta-S), a general protein kinase inhibitor (H7), or selective inhibitors of protein kinase C (NPC15437), protein kinase A (H89), or protein kinase G (KT5823) into the spinal cord dorsal horn reversed the mechanical allodynia induced by intradermal injection of capsaicin in a dose-dependent manner by increasing the threshold to mechanical stimulation towards baseline. "
5. Ischemia

Related Drugs and Biologics

1. N- (2- (4- bromocinnamylamino)ethyl)- 5- isoquinolinesulfonamide (h89)
2. Phosphotransferases (Kinase)
3. Staphylococcal Protein A (A, Protein)
4. protein kinase modulator
5. Calcium-Calmodulin-Dependent Protein Kinase Type 2
6. Tretinoin (Retinoic Acid)
7. Hydrocortisone (Cortisol)
8. bisindolylmaleimide
9. KN 93
10. KN 62

Related Therapies and Procedures

1. Intraventricular Infusions
2. Vagus Nerve Stimulation
3. Intradermal Injections