2- butyl- 4- chloro- 1- ((2'- (1H- tetrazol- 5- yl)(1,1'- biphenyl)- 4- yl)methyl)- 1H- imidazole- 5- carboxaldehyde

aldehyde derivative of DuP 753; angiotensin II receptor blocker; a losartan metabolite lacking AT1R blocking properties

Also Known As:

EXP 132; EXP 3179; EXP-132; EXP-3179; EXP132; EXP3179

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        Losartan: 3769
        2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-carboxaldehyde: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Losartan: 3769
        2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-carboxaldehyde: 5
    - Tetrazoles: 14
      - Losartan: 3769
        2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-carboxaldehyde: 5

Experts

1.	Díez, Javier: 2 articles (01/2017 - 10/2009)
2.	Fortuño, Ana: 2 articles (01/2017 - 10/2009)
3.	Zalba, Guillermo: 2 articles (01/2017 - 10/2009)
4.	Abadir, Peter M: 1 article (05/2022)
5.	Anders, Nicole M: 1 article (05/2022)
6.	Bichara, Marcela-Dávalos: 1 article (05/2022)
7.	Buta, Brian: 1 article (05/2022)
8.	Carey, Robert M: 1 article (05/2022)
9.	Ferrucci, Luigi: 1 article (05/2022)
10.	Gabrawy, Mariann M: 1 article (05/2022)

Related Diseases

1.	Inflammation (Inflammations) 12/29/2022 - "Losartan is an oral antihypertensive agent that is rapidly metabolized to EXP3174 (angiotensin-subtype-1-receptor blocker) and EXP3179 (peroxisome proliferator-activated receptor gamma [PPARγ] agonist), which was shown in animal studies to reduce inflammation, enhance mitochondrial energetics, and improve muscle repair and physical performance. "
2.	Hypertension (High Blood Pressure) 01/01/2017 - "Our aim was to investigate the differential influence of losartan metabolites on myocardial LOX and CCL in an experimental model of hypertension with myocardial fibrosis, and whether EXP3179 and EXP3174 modify LOX expression and activity in fibroblasts. " 10/01/2009 - "Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension."
3.	Atherosclerotic Plaque (Atheroma) 05/01/2007 - "EXP3179 also reduced human atherosclerotic plaque material-induced platelet aggregation (P<0.01) in vitro and murine platelet adhesion after acute vessel injury in vivo as determined by intravital microscopy (P<0.01). " 05/01/2007 - "Thrombus formation after atherosclerotic plaque rupture critically involves the platelet collagen receptor glycoprotein (GP) VI. We investigated the impact of EXP3179, an active metabolite of the angiotensin II type 1 (AT1)-receptor antagonist Losartan (LOS) on GPVI-dependent platelet activation. "
4.	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/01/2009 - "Losartan metabolite EXP3179: an AT1-receptor-independent treatment strategy for patients with the metabolic syndrome?"
5.	Thrombosis (Thrombus) 05/01/2007 - "EXP3179 inhibits collagen-dependent platelet activation via glycoprotein receptor-VI independent of AT1-receptor antagonism: potential impact on atherothrombosis." 05/01/2007 - "Thrombus formation after atherosclerotic plaque rupture critically involves the platelet collagen receptor glycoprotein (GP) VI. We investigated the impact of EXP3179, an active metabolite of the angiotensin II type 1 (AT1)-receptor antagonist Losartan (LOS) on GPVI-dependent platelet activation. "

Related Drugs and Biologics

1.	Losartan (Cozaar)
2.	losartan carboxylic acid
3.	PPAR gamma
4.	Antihypertensive Agents (Antihypertensives)
5.	Angiotensin II
6.	Connective Tissue Growth Factor
7.	Collagen Receptors
8.	NG-Nitroarginine Methyl Ester (L-NAME)
9.	NADPH Oxidases (NAD(P)H oxidase)
10.	Superoxides (Superoxide)