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2-crotonyloxymethyl-2-cyclohexenone

structure given in first source

Also Known As:

2-COMC; 2-crotonyloxymethyl-cyclohex-2-enone; COMC-6

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Cyclohexanones: 5
    - 2-crotonyloxymethyl-2-cyclohexenone: 1
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexanones: 5
        2-crotonyloxymethyl-2-cyclohexenone: 1

Experts

1.	Creighton, Donald J: 1 article (01/2003)
2.	Ding, Zhebo: 1 article (01/2003)
3.	Eiseman, Julie L: 1 article (01/2003)
4.	Ganem, Bruce: 1 article (01/2003)
5.	Hamilton, Diana S: 1 article (01/2003)
6.	Joseph, Erin: 1 article (01/2003)
7.	Tak, Heekyung: 1 article (01/2003)
8.	Wang, Haibo: 1 article (01/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/02/2003 - "The antitumor activity of 2-crotonyloxymethyl-2-cyclohexenone (COMC-6) is not the result of the GSH conjugate (GSMC-6) formed inside tumor cells, as the diethyl ester prodrug form of GSMC-6 displays little antitumor activity with B16 melanotic melanoma in vitro (IC(50) > 460 microM) versus COMC-6 (IC(50) 0.041 microM) and its five- and seven-membered ring homologues. "
2.	Melanoma (Melanoma, Malignant) 01/02/2003 - "The antitumor activity of 2-crotonyloxymethyl-2-cyclohexenone (COMC-6) is not the result of the GSH conjugate (GSMC-6) formed inside tumor cells, as the diethyl ester prodrug form of GSMC-6 displays little antitumor activity with B16 melanotic melanoma in vitro (IC(50) > 460 microM) versus COMC-6 (IC(50) 0.041 microM) and its five- and seven-membered ring homologues. "

Related Drugs and Biologics

1.	2-crotonyloxymethyl-2-cyclohexenone
2.	Prodrugs
3.	Esters