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N-leucyldoxorubicin

structure given in first source; a prodrug of doxorubicin

Also Known As:

N-L-leucyl-doxorubicin; N-L-leucyldoxorubicin; N-leucyl-doxorubicin; leucyl-doxorubicin

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Arriaga, Edgar A: 1 article (04/2008)
2.	Wang, Yaohua: 1 article (04/2008)
3.	Abarca-Quinones, J: 1 article (04/2001)
4.	Baurain, R: 1 article (04/2001)
5.	Dubois, V: 1 article (04/2001)
6.	Fernandez, A M: 1 article (04/2001)
7.	Lobl, T J: 1 article (04/2001)
8.	Oliyai, C: 1 article (04/2001)
9.	Passioukov, A: 1 article (04/2001)
10.	Shochat, D: 1 article (04/2001)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 07/01/1999 - "Superior therapeutic efficacy of N-L-leucyl-doxorubicin versus doxorubicin in human melanoma xenografts correlates with higher tumour concentrations of free drug."
2.	Neoplasms (Cancer) 03/01/1992 - "A pharmacokinetic study of N-L-leucyl-doxorubicin, a new derivative of doxorubicin, has been undertaken during a phase I trial in 19 patients with advanced cancer after intravenous bolus administration at doses ranging from 30 to 240 mg/m2. " 04/01/2001 - "A two-step activation by peptidases found in conditioned media of cancer cells ultimately yields N-L-leucyl-doxorubicin. "
3.	Cardiotoxicity 12/01/1992 - "N-l-leucyldoxorubicin (Leu-Dox) was developed as a prodrug of doxorubicin (Dox) to circumvent the cardiotoxicity associated with repeated administration of Dox. "
4.	Sarcoma (Soft Tissue Sarcoma) 04/08/2008 - "Monitoring incorporation, transformation and subcellular distribution of N-l-leucyl-doxorubicin in uterine sarcoma cells using capillary electrophoretic techniques."
5.	Ovarian Neoplasms (Ovarian Cancer) 12/01/1992 - "N-l-leucyl-doxorubicin induced a growth inhibition > 50% in three out of four human ovarian cancer lines. " 12/01/1992 - "The anti-tumour effects of the prodrugs N-l-leucyl-doxorubicin and vinblastine-isoleucinate in human ovarian cancer xenografts."

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)
2.	Prodrugs
3.	Conditioned Culture Media
4.	Peptide Hydrolases (Proteases)
5.	vinleucinol