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RO 23-6152
Also Known As:
(+)-cis-3-(acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-5-(2-(dimethylamino)ethyl)naptho-(1,2-b)-1,4-thiazepin-4(5H)one hydrochloride; R023-6152; R0236152; RO-23-6152; RO236152
Networked:
2
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzazepines: 5
Diltiazem: 2789
RO 23-6152: 2
Related Diseases
1.
Thrombosis (Thrombus)
10/01/1991 - "
The results indicate that both R023-6152 and diltiazem are effective in suppressing in vivo platelet aggregation associated with occlusive coronary thrombus formation.
"
2.
Coronary Thrombosis
10/01/1991 - "
In this study, we compared the platelet antiaggregatory effects of R023-6152, a thiazepinone-type calcium antagonist, with diltiazem in an in vivo canine model of spontaneous coronary thrombosis.
"
3.
Coronary Occlusion
10/01/1991 - "
Dogs receiving intravenous (i.v.) R023-6152 (200 micrograms/kg) or diltiazem (50 micrograms/kg) immediately after the current was discontinued exhibited no significant elevations in 5-HT values (12.3 +/- 1.4 and 1.84 +/- 0.42 ng/ml for R023-6152 and diltiazem, respectively) or development of coronary occlusions in the next 3 h.
"
4.
Essential Hypertension
01/01/1991 - "
Hemodynamic effects of Ro 23-6152 in patients with essential hypertension.
"
01/01/1991 - "
In a double blind study 8 patients with uncomplicated essential hypertension received in random order single oral doses of placebo and 10, 30 and 80 mg Ro 23-6152, a novel calcium entry blocker, on 4 different days.
"
Related Drugs and Biologics
1.
Diltiazem (Cardizem)
2.
Calcium
3.
Serotonin (5 Hydroxytryptamine)