6-phenylhexyl isothiocyanate

08/01/1993 - "In this study, we compared the ability of PBY, PPY, 2-EN and PHITC to inhibit A/J mouse lung tumorigenesis by NNK. "
01/10/2001 - "To test the hypothesis that PHITC influences the promotional stage of esophageal tumorigenesis, groups of 22-27 rats were dosed with vehicle or NMBA three times a week for 5 week, and fed a modified AIN-76A diet containing PHITC at concentrations of 0.0, 1.0, and 2.5 micromol/g. "
04/01/1997 - "However, dietary PHITC blocked the process of apoptosis during colon carcinogenesis. "
01/15/1997 - "Mechanism of enhancement of esophageal tumorigenesis by 6-phenylhexyl isothiocyanate."
10/01/1995 - "Enhancement of experimental colon carcinogenesis by dietary 6-phenylhexyl isothiocyanate."

09/01/1996 - "PHITC had no effect on the total incidence of exocrine pancreatic tumors induced by NNK. "
09/01/1996 - "In the rats treated with NNK plus PHITC, the total percent incidence of lung tumors was 26% (P < 0.01 compared with NNK). "
10/01/1995 - "Dietary PHITC also increased the colon tumor volume (2- to 4.3-fold) in a dose-dependent manner. "
10/01/1995 - "In contrast, all rats treated with NMBA alone or PHITC + NMBA exhibited esophageal tumors and preneoplastic esophageal lesions. "
10/01/1995 - "No esophageal tumors or preneoplastic lesions were detected in rats that received the vehicle or PHITC alone. "

10/01/1995 - "At the 640-ppm dose level, dietary PHITC significantly increased the incidence of intestinal (small intestine plus colon) adenocarcinomas (P < 0.05) as well as the multiplicities of invasive and noninvasive adenocarcinomas of the colon (P < 0.05 to 0.01). "
11/01/1994 - "The present study was conducted to investigate the effect of sulindac and PHITC on azoxymethane (AOM)induced activation of ras proto-oncogenes in order to explore the plausibility of using ras as an intermediate biomarker in chemoprevention of colon cancer. "
04/01/1997 - "Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion."

04/10/2003 - "No bladder tumors were found in animals of groups 5-8. The results in the present study clearly indicate that both MESNA and PHITC are potent chemopreventive agents against bladder tumor development in rats induced by BHBN."
04/10/2003 - "The incidences of papillomas in the bladder and total bladder tumors including transitional cell carcinomas were significantly (P<0.01) reduced in group 2 as compared to that in group 1. The multiplicities of papillomas or total bladder tumors were significantly (P<0.01) lower in group 2 and 4 rats treated with MESNA and PHITC, respectively, than in group 1 rats. "

04/10/2003 - "The incidences of papillomas in the bladder and total bladder tumors including transitional cell carcinomas were significantly (P<0.01) reduced in group 2 as compared to that in group 1. The multiplicities of papillomas or total bladder tumors were significantly (P<0.01) lower in group 2 and 4 rats treated with MESNA and PHITC, respectively, than in group 1 rats. "