WR 182393

a guanide antimalarial drug

Also Known As:

1-(3,4-dichlorophenyl)-3-(1-isopropyl-4,5-dioxo-2-imidazolidinylidine)guanide; WR-182393; WR182393; Guanidine, N-(3,4-dichlorophenyl)-N'-(4,5-dihydro-1-(1-methylethyl)-4,5-dioxo-1H-imidazol-2-yl)-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - WR 182393: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - WR 182393: 2

Related Diseases

1.	Malaria 10/01/1993 - "Compound WR182393 is the first non-8-aminoquinoline class of drug to exhibit both causal prophylactic and radical curative properties against a relapsing primate, vivax-like malaria."
2.	Infections 02/01/1992 - "Significant numbers of macrogametocytes and microgametocytes were present throughout the duration of the infection in mice treated with halofantrine, primaquine, WR-182393, and WR-238605. "

Related Drugs and Biologics

1.	Primaquine
2.	tafenoquine
3.	halofantrine (Halfan)