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SDZ PCO 400
a potassium channel opening drug
Also Known As:
3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(3-oxo-cyclopent-1-enyloxy)-2H-1-benzopyran-6-carbonitrile; SDZ PCO-400; 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-((3-oxo-1-cyclopenten-1-yl)oxy)-, (3S-trans)-
Networked:
4
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
SDZ PCO 400: 4
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
SDZ PCO 400: 4
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Alicyclic Hydrocarbons: 1
Cycloparaffins: 6
Cyclopentanes: 58
SDZ PCO 400: 4
Related Diseases
1.
Ischemic Contracture
08/01/1993 - "
In animal PVD models, SDZ PCO-400 and cromakalim have been shown to improve recovery of muscle energy stores from ischemia or to preserve performance under conditions of ischemic contracture.
"
2.
Ischemia
08/01/1993 - "
In animal PVD models, SDZ PCO-400 and cromakalim have been shown to improve recovery of muscle energy stores from ischemia or to preserve performance under conditions of ischemic contracture.
"
3.
Airway Obstruction (Choking)
06/01/1992 - "
This effect was prevented by prior vagal section.7. It is concluded that SDZ PCO 400 reduces airway obstruction not only through direct actions on airway smooth muscle but also by impairing the expression of airway hyperreactivity, without directly influencing inflammatory events in the airways.
"
06/01/1992 - "
2. Airway obstruction induced by intravenous bombesin in the anaesthetized ventilated guinea-pig was diminished by intravenous injection of SDZ PCO 400 (ID50 54 micrograms kg-1) or by introduction into the duodenum (ID50 1.0 mg kg-1).
"
06/01/1992 - "
However in anaesthetized sensitized guinea-pigs,insufflation of SDZ PCO 400 (1.25 mg) as a powder substantially diminished airway obstruction that followed inhalation of ovalbumin.
"
01/01/1991 - "
SDZ PCO 400, and cromakalim are potassium channel opening drugs which relax airway smooth muscle and reverse airway obstruction due to intravenous administration of airway spasmogens.
"
01/01/1991 - "
Reduction of airway obstruction by these drugs may be attributed to actions upon airway reactivity as well as airway smooth muscle spasmolysis; for, at concentrations which do not induce overt relaxation of airway smooth muscle, both SDZ PCO 400 and cromakalim suppressed development of airway hyperreactivity due to administration of immune complexes, PAF or (+/-)isoprenaline and reversed established airway hyperreactivity due to allergic reactions.
"
4.
Spasm (Spasms)
08/14/1992 - "
In bovine and guinea-pig trachea, SDZ PCO 400 (10 microM) suppressed spasm evoked by lower (less than 40 mM) but not higher (greater than 40 mM) concentrations of KCl.
"
08/14/1992 - "
The relaxant action of SDZ PCO 400 was ablated when spasm was induced by a K(+)-rich (120 mM) medium.
"
5.
Hypersensitivity (Allergy)
01/01/1991 - "
Reduction of airway obstruction by these drugs may be attributed to actions upon airway reactivity as well as airway smooth muscle spasmolysis; for, at concentrations which do not induce overt relaxation of airway smooth muscle, both SDZ PCO 400 and cromakalim suppressed development of airway hyperreactivity due to administration of immune complexes, PAF or (+/-)isoprenaline and reversed established airway hyperreactivity due to allergic reactions.
"
Related Drugs and Biologics
1.
Cromakalim (Levcromakalim)
2.
Isoproterenol (Isoprenaline)
3.
Antigen-Antibody Complex (Immune Complex)
4.
Potassium Channels (Potassium Channel)
5.
Powders
6.
Platelet Activating Factor
7.
Ovalbumin
8.
Ketotifen (Ketotifene)
9.
Histamine (Histamine Dihydrochloride)
10.
Bombesin
Related Therapies and Procedures
1.
Intravenous Administration
2.
Intravenous Injections
3.
Intravenous Infusions