SDZ PCO 400

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4 relevant articles (1 outcomes, 0 trials/studies) found for this Bio-Agent

Description: a potassium channel opening drug

Also Known As:

3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(3-oxo-cyclopent-1-enyloxy)-2H-1-benzopyran-6-carbonitrile; SDZ PCO-400; 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-((3-oxo-1-cyclopenten-1-yl)oxy)-, (3S-trans)-

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 23

Pyrans: 3

Benzopyrans: 5

SDZ PCO 400: 4

2-Ring Heterocyclic Compounds

Benzopyrans: 5

SDZ PCO 400: 4

Organic Chemicals: 40

Hydrocarbons: 382

Cyclic Hydrocarbons: 2

Alicyclic Hydrocarbons: 1

Cycloparaffins: 3

Cyclopentanes: 30

SDZ PCO 400: 4

Related Diseases

1.	Ischemic Contracture 08/01/1993 - "In animal PVD models, SDZ PCO-400 and cromakalim have been shown to improve recovery of muscle energy stores from ischemia or to preserve performance under conditions of ischemic contracture" Get all the results and reference details, order at left...
2.	Ischemia 08/01/1993 - "In animal PVD models, SDZ PCO-400 and cromakalim have been shown to improve recovery of muscle energy stores from ischemia or to preserve performance under conditions of ischemic contracture" Get all the results and reference details, order at left...
3.	Airway Obstruction (Choking) 06/01/1992 - "2. Airway obstruction induced by intravenous bombesin in the anaesthetized ventilated guinea-pig was diminished by intravenous injection of SDZ PCO 400 (ID50 54 micrograms kg-1) or by introduction into the duodenum (ID50 1.0 mg kg-1)" 01/01/1991 - "SDZ PCO 400, and cromakalim are potassium channel opening drugs which relax airway smooth muscle and reverse airway obstruction due to intravenous administration of airway spasmogens" 01/01/1991 - "Reduction of airway obstruction by these drugs may be attributed to actions upon airway reactivity as well as airway smooth muscle spasmolysis; for, at concentrations which do not induce overt relaxation of airway smooth muscle, both SDZ PCO 400 and cromakalim suppressed development of airway hyperreactivity due to administration of immune complexes, PAF or (+/-)isoprenaline and reversed established airway hyperreactivity due to allergic reactions" 06/01/1992 - "Inhalation of nebulized SDZ PCO 400 (0.1 mg kg-1) diminished airway obstruction due to intravenous injection of histamine (3.2-5.6 micrograms kg-1) for up to 20 min. 3. Increased bronchoconstrictor responses to bombesin (180-240 ng kg-1) following intravenous infusion of platelet activating factor (PAF) or (+/-)-isoprenaline, or to histamine (1.0-3.2 micrograms kg-1) following intravenous injections of immune complexes, were suppressed following concomitant intravenous infusion of SDZ PCO 400 (ID50 0.3 mg kg-1 h-1, 1.0 mg kg-1 h-1 and 0.1 mg kg-1 h-1 respectively)" Get all the results and reference details, order at left...
4.	Spasm (Spasms) 08/14/1992 - "In bovine and guinea-pig trachea, SDZ PCO 400 (10 microM) suppressed spasm evoked by lower (less than 40 mM) but not higher (greater than 40 mM) concentrations of KCl" 08/14/1992 - "The relaxant action of SDZ PCO 400 was ablated when spasm was induced by a K(+)-rich (120 mM) medium" Get all the results and reference details, order at left...
5.	Hypersensitivity (Allergy) 01/01/1991 - "Reduction of airway obstruction by these drugs may be attributed to actions upon airway reactivity as well as airway smooth muscle spasmolysis; for, at concentrations which do not induce overt relaxation of airway smooth muscle, both SDZ PCO 400 and cromakalim suppressed development of airway hyperreactivity due to administration of immune complexes, PAF or (+/-)isoprenaline and reversed established airway hyperreactivity due to allergic reactions" Get all the results and reference details, order at left...
8 Diseases and 4 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Cromakalim (Levcromakalim)
2.	Isoproterenol (Isoprenaline)
3.	Antigen-Antibody Complex (Immune Complex)
4.	Potassium Channels (Potassium Channel)
5.	Platelet Activating Factor
6.	Ketotifen (Ketotifene)
7.	Histamine (Histamine Dihydrochloride)
8.	Bombesin
9.	Aerosols
9 Drugs and Important Bio-Agents and 3 more articles analyzed in the Research Interface, order at left...

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