hydroxyacid-oxoacid transhydrogenase

forms succinic semialdehyde and alpha-hydroxyglutarate from gamma-hydroxybutyrate plus alpha-ketoglutarate

Also Known As:

(s)-3-hydroxybutanoate -2-oxoglutarate oxidoreductase; ADHFE1 protein, human; Adhfe1 protein, mouse; Adhfe1 protein, rat; D-2-hydroxyglutarate transhydrogenase; GHB-alphaKG transhydrogenase; alcohol dehydrogenase, iron containing, 1 human; alcohol dehydrogenase, iron containing, 1 protein, mouse; alcohol dehydrogenase, iron containing, 1 protein, rat; gamma-hydroxybutyrate-alpha-ketoglutarate transhydrogenase

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Berthelot, J: 1 article (05/2006)
2.	Chabrier, S: 1 article (05/2006)
3.	Gibson, K M: 1 article (05/2006)
4.	Jakobs, C: 1 article (05/2006)
5.	Salomons, G S: 1 article (05/2006)
6.	Struys, E A: 1 article (05/2006)
7.	Thomas, J A: 1 article (05/2006)
8.	Tsai, A Chun-Hui: 1 article (05/2006)
9.	Verhoeven, N M: 1 article (05/2006)
10.	Vianay-Saban, C: 1 article (05/2006)

Related Diseases

1.	succinic semialdehyde dehydrogenase deficiency 05/01/2006 - "The increase of D-2-HG in SSADH deficiency can be explained by the action of hydroxyacid-oxoacid transhydrogenase, a reversible enzyme that oxidases GHB in the presence of 2-ketoglutarate yielding SSA and D-2-HG."

Related Drugs and Biologics

1.	Oxidoreductases (Dehydrogenase)
2.	Ketoglutaric Acids (Ketoglutaric Acid)
3.	Enzymes