guanylin

from rat jejunum; contains 15 amino acids; activator of intestinal guanylate cyclase; stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; amino acid sequence given in first source; GenBank Z73607 (pig)

Networked: 97 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Waldman, Scott A: 14 articles (01/2022 - 08/2007)
2.	Snook, Adam E: 7 articles (01/2022 - 11/2013)
3.	Li, Peng: 5 articles (11/2014 - 08/2007)
4.	Cohen, Mitchell B: 5 articles (09/2013 - 12/2002)
5.	Steinbrecher, Kris A: 5 articles (09/2013 - 12/2002)
6.	Cetin, Yalcin: 5 articles (05/2012 - 08/2002)
7.	Visweswariah, Sandhya S: 4 articles (11/2021 - 08/2012)
8.	Lin, Jieru E: 4 articles (06/2017 - 11/2013)
9.	Mann, Elizabeth A: 4 articles (09/2013 - 01/2004)
10.	Kulaksiz, Hasan: 4 articles (01/2008 - 08/2002)

Related Diseases

1.	Carcinogenesis 09/01/2016 - "Indeed, genetically enforced guanylin replacement eliminated diet-induced intestinal tumorigenesis in mice. " 01/01/2019 - "High-calorie diet-induced obesity is associated with deficiency of guanylin expression and silencing of GUCY2C-signaling in colon epithelial cells, leading to tumorigenesis. " 09/01/2016 - "Importantly, calorie-induced guanylin loss silences the GUCY2C-cGMP paracrine axis underlying obesity-induced epithelial dysfunction and colorectal tumorigenesis. " 01/15/2016 - "Using genetically engineered mice on different diets, we found that diet-induced obesity caused a loss of guanylin expression in the colon with subsequent GUCY2C silencing, epithelial dysfunction, and tumorigenesis. " 01/01/2020 - "The intestinal epithelial receptor, GUCY2C, with its canonical paracrine hormone guanylin, regulates homeostatic signaling along the crypt-surface axis opposing tumorigenesis. "
2.	Neoplasms (Cancer) 01/15/2016 - "In transgenic mice, enforcing specific expression of guanylin in intestinal epithelial cells restored GUCY2C signaling, eliminating intestinal tumors associated with a high calorie diet. " 09/01/2009 - "The positive expression of guanylin in normal tissue (80%, 16/20) was significantly higher than that in tumor tissue (35%, 7/20) (P<0.01). " 06/24/2000 - "Previously, we mapped the guanylin gene to mouse and human chromosomal regions containing multiple intestinal tumor-modifying loci. " 09/01/2009 - "There is differential expression of guanylin in colorectal cancer, and this kind of differential expression is associated with tumor TNM stage." 08/01/2002 - "Moreover, the high expression of guanylin in pleomorphic adenoma and Warthin tumors (cystadenolymphoma), the most common neoplasms of salivary glands, predicts guanylin as a significant marker in tumor pathology."
3.	Cystic Fibrosis (Mucoviscidosis) 05/01/1994 - "5. The action of guanylin was virtually eliminated in colonic epithelia from transgenic cystic fibrosis (CF) mice. " 12/01/1996 - "Guanylin and heat-stable enterotoxin (STa) stimulate intestinal Cl- secretion via activation of the cystic fibrosis transmembrane regulator (CFTR)-encoded Cl- channel. " 05/01/1994 - "Chloride secretion in response to guanylin in colonic epithelial from normal and transgenic cystic fibrosis mice." 05/01/2012 - "Guanylin, a bioactive intestinal peptide, is involved in the cystic fibrosis transmembrane conductance (CFTR)-regulated electrolyte/water secretion in various epithelia. " 08/01/2002 - "Guanylin and uroguanylin are intestinal or urine peptides that stimulate epithelial electrolyte/fluid secretion by activating the cystic fibrosis gene product (CFTR). "
4.	Carcinoma (Carcinomatosis) 09/01/2001 - "Guanylin peptides possess antiproliferative activity in intestinal cells culture and their expression decreases in colonic carcinoma indicating that their deficiency may contribute to the pathogenesis of this disease." 03/01/2001 - "Extracts of intestinal epithelia from the European eel (Anguilla anguilla) stimulated cGMP production in the T84 human colon carcinoma cell line which suggested the presence of a guanylin-like peptide in this teleost fish. " 01/01/2020 - "Similarly, in FAP patients, normal colonic mucosa (monoallelic APC loss) expressed guanylin while adenomas and an invasive carcinoma (biallelic APC loss) were devoid of hormone expression. " 11/01/1993 - "Guanylin, a recently discovered rat intestinal peptide, is homologous in structure to ST I and can activate guanylate cyclase present on the human colonic carcinoma cell line T84. " 03/01/2002 - "Recent findings that expression of uroguanylin and guanylin is dramatically reduced in polyps and colon carcinoma tissues further support the notion that these peptide hormones are important modulators or mediators of signaling pathways leading to the processes involved in carcinogenesis and inflammatory disorders. "
5.	Polyps 09/15/2000 - "Our experiments demonstrate that mRNA transcripts for guanylin and uroguanylin are markedly reduced in colon polyps and adenocarcinomas. " 03/01/2002 - "Recent findings that expression of uroguanylin and guanylin is dramatically reduced in polyps and colon carcinoma tissues further support the notion that these peptide hormones are important modulators or mediators of signaling pathways leading to the processes involved in carcinogenesis and inflammatory disorders. "

Related Drugs and Biologics

1.	uroguanylin
2.	Peptides (Polypeptides)
3.	Hormones (Hormone)
4.	Peptide Hormones (Polypeptide Hormones)
5.	Catenins
6.	Ligands
7.	Enterotoxins (Enterotoxin)
8.	Enterotoxin Receptors
9.	Guanylate Cyclase (Guanylyl Cyclase)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Oral Administration
2.	Bariatric Surgery
3.	Therapeutics
4.	Gastric Bypass (Roux-en-Y Gastric Bypass)
5.	Nephrectomy