cyclic- 1- (3- hydroxy- 2- phosphonylmethoxypropyl)cytosine

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11 relevant articles (1 outcomes, 1 trials/studies) found for this Bio-Agent

Description: prodrug for HPMPC; specific name and structure not given in first source

Also Known As:

1-(((S)-2-Hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl)cytosine (cyclic HPMPC); 1-((-2-Hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl)cytosine (cyclic HPMPC); 1-((2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl)cytosine; 2-HO-DOPM cHPMPC; cHPMPC; cyclic HPMPC; cyclic-HPMPC

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 40

Organophosphorus Compounds: 126

cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine: 11

Heterocyclic Compounds: 23

1-Ring Heterocyclic Compounds

Pyrimidines: 269

Pyrimidinones: 13

Cytosine: 769

cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine: 11

Experts

1.	Bernstein, David I: 1 article (02/2006)
2.	Cardin, Rhonda D: 1 article (02/2006)
3.	Bravo, Fernando J: 1 article (02/2006)
4.	Anderson, Jodi L: 1 article (01/2006)
5.	Schleiss, Mark R: 1 article (01/2006)
6.	McGregor, Alistair: 1 article (01/2006)
7.	Sidwell, Robert W: 1 article (06/2003)
8.	Smee, Donald F: 1 article (06/2003)
9.	Bailey, Kevin W: 1 article (06/2003)
10.	Bernstein, D I: 1 article (08/2000)

Related Diseases

1.	Infection 08/01/2000 - "Cyclic HPMPC is safe and effective against systemic guinea pig cytomegalovirus infection in immune compromised animals." 08/01/2000 - "In efficacy studies in immune compromised guinea pigs challenged with a virulent salivary gland passaged guinea pig CMV, CHPMPC treatment significantly reduced mortality resulting from disseminated virus infection" 02/15/2006 - "CONCLUSIONS: Treatment of the GPCMV-infected pregnant dam with 1 dose of cHPMPC improves the outcome of congenital infection and decreases viral replication in a guinea pig model." 02/15/2006 - "cHPMPC treatment did not prevent infection of the placenta or disseminated infection of the dam and pup but significantly decreased the amount of GPCMV in tissues" 02/15/2006 - "Guinea pigs were monitored until delivery or were killed 10 days after infection, for the evaluation of the effect of cHPMPC on viral replication by polymerase chain reaction analysis in various dam and pup tissues" Order ALL the reference details at left...
2.	Herpesviridae Infections (Herpesvirus Infection) 08/01/2000 - "The efficacy of CHPMPC combined with its improved safety profile appear to make it an attractive alternative to cidofovir for the treatment of herpesvirus infections" Order ALL the reference details at left...
3.	Cowpox 07/01/2008 - "In gastrointestinal and liver homogenates, the cHPMPC prodrugs are rapidly hydrolyzed to 2. Prodrugs 3, 4, and 5 are nontoxic at 100 microM in HFF and KB cells and in cell-based plaque reduction assays had IC 50 values of 0.1-0.5 microM for HCMV and 10 microM for two orthopox viruses (vaccinia and cowpox)" 06/01/2003 - "Comparative effects of cidofovir and cyclic HPMPC on lethal cowpox and vaccinia virus respiratory infections in mice." Order ALL the reference details at left...
4.	Cytomegalovirus Infections (Inclusion Disease) 02/15/2006 - "Effect of maternal treatment with cyclic HPMPC in the guinea pig model of congenital cytomegalovirus infection." 01/01/2006 - "Cyclic cidofovir (cHPMPC) prevents congenital cytomegalovirus infection in a guinea pig model." Order ALL the reference details at left...
5.	Weight Gain 09/01/2003 - "Antiviral treatment with cyclic HPMPC (cHPMPC) for 7 days significantly reduced mortality (1/20 versus 14/20, P<0.001) and viral replication but did not improve weight gain" Order ALL the reference details at left...

Related Drugs and Biologics

1.	cidofovir (Vistide)
2.	cyclic- 1- (3- hydroxy- 2- phosphonylmethoxypropyl)cytosine
3.	Ribavirin (Virazole)
4.	Cytosine
5.	9- (3- hydroxy- 2- phosphonylmethoxypropyl)adenine
6.	Foscarnet
7.	Ganciclovir (Cytovene)
8.	Tubercidin
9.	Prodrugs
10.	Mycophenolic Acid

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