|1.||Webb, D J: 6 articles (09/2006 - 07/2000)|
|2.||Gulati, Anil: 5 articles (11/2015 - 10/2002)|
|3.||Rae, Giles A: 5 articles (10/2010 - 07/2004)|
|4.||Pernow, John: 4 articles (01/2008 - 03/2002)|
|5.||Rae, Giles Alexander: 3 articles (07/2009 - 06/2006)|
|6.||Webb, David J: 3 articles (07/2009 - 08/2002)|
|7.||D'Orléans-Juste, Pedro: 3 articles (05/2009 - 01/2006)|
|8.||Böhm, Felix: 3 articles (03/2007 - 03/2002)|
|9.||Newby, D E: 3 articles (09/2006 - 03/2003)|
|10.||Baamonde, Ana: 3 articles (04/2004 - 01/2003)|
01/01/2001 - "Most impressively, treatment with the selective ET(A) receptor antagonist BQ123 significantly improved survival in an experimental model of heart failure. "
07/01/2000 - "BQ-123 (100 nmol/min) increased blood flow by 54+/-10% (P<0.001) and 30+/-5% (P<0.001) in controls and heart failure patients, respectively. "
06/20/2000 - "We reported that long-term (3-month) treatment with the endothelin (ET) type A (ET(A)) receptor antagonist BQ-123 markedly improved survival in rats with chronic heart failure (CHF). "
11/01/2001 - "As both the mixed ETA/ETB-receptor antagonist bosentan and the selective ETA receptor antagonist BQ 123 acutely improved the haemodynamics of chronic heart failure patients, there seems to be good reason to believe that ET-1 receptor antagonism may also be of benefit in the setting of acute heart failure. "
01/01/1998 - "These findings suggest that long-term BQ-123 treatment inhibits the change in MHC isoforms and suggest that this treatment ameliorates heart failure in CHF rats at the molecular level."
|2.||Pulmonary Hypertension (Ayerza Syndrome)
11/15/1996 - "Long-term BQ-123 treatment greatly ameliorated pulmonary hypertension in the CHF rats. "
03/01/1996 - "Pulmonary vasodilation to BQ 123 (100 mu g/min for 10 min) was greater during late than early pulmonary hypertension (43 versus 21%; p < 0.05). "
04/01/1994 - "We conclude that the ETA-receptor antagonist BQ123 attenuates the development of hypoxic pulmonary hypertension in rats in vivo, thereby suggesting a possible contributing role for ET-1 and the ETA receptor in the pathogenesis of this process."
04/01/1994 - "BQ123, an ETA-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats."
03/01/1996 - "To examine the effects of experimental perinatal pulmonary hypertension on activity of the ETA and ETB receptors, we studied the hemodynamic effects of ET-3, ET-1 (a nonselective ETA and ETB receptor agonist), and BQ 123 (a selective ETA receptor antagonist) in 12 chronically prepared late gestation fetal lambs after partial ligation of the ductus arteriosus. "
07/01/1999 - "In the present study, we tried to protect rat model from developing into hemorrhagic pancreatitis with BQ123 (an ETA receptor antagonist). "
07/01/2007 - "Pretreatment of neutrophils with BQ-123 inhibited the detachment caused by neutrophils from healthy donors but not by neutrophils from acute pancreatitis patients. "
08/28/2012 - "In a second study, groups of animals with DBTC-induced pancreatitis were treated with endothelin (ET) receptor antagonists [ET-A (BQ123) and ET-B BQ788)]. "
06/01/1995 - "To clarify the involvement of endothelin-1 in acute pancreatitis, we examined the effects of endothelin-1 and its receptor antagonist BQ-123 on cerulein-induced pancreatitis in rats. "
08/28/2012 - "Treatments with the ET-A (BQ123) and ET-B (BQ-788) antagonists revealed significant protection against inflammatory pain related mechanical and thermal hypersensitivity behaviors in animals with pancreatitis (P < 0.05). "
|4.||Myocardial Ischemia (Ischemic Heart Diseases)
02/15/2006 - "Therefore, this study was focused to investigate the effect of BQ-123, selective ETA receptor antagonist, on three aspects of myocardial ischemia-reperfusion (MI/R) injury: hemodynamic parameters, infarct size and oxidant-antioxidant status in the absence and presence of ET-1 in an vivo rat model. "
11/01/2009 - "To study the protective effects of ramipril in combination with BQ-123 on myocardial ischemia/reperfusion (I/R) injury in vivo in anesthetized rats. "
11/01/2009 - "[Cardioprotection of ramipril and BQ-123 against myocardial ischemia/reperfusion injury in vivo in rats]."
02/01/1995 - "A potential detrimental role of endothelin-1 in myocardial ischemia/reperfusion injury was studied by use of the endothelin-1 antagonists BQ123 and BQ610. "
03/01/2003 - "During the "NO clamp", BQ-123 induced vasodilatation was abolished in controls and attenuated in patients (p<0.001) but remained significantly greater in patients with cirrhosis (p<0.01). "
04/15/2006 - "BQ-123 for 28 days significantly reduced the histological appearance of cardiac fibrosis. "
10/01/2003 - "Responses to BQ123 were not different in patients with advanced cirrhosis compared with controls. "
03/01/2003 - "Before applying the "NO clamp", BQ-123 caused an increase in FBF in both groups (p<0.001) that was greater in patients with cirrhosis (p<0.01). "
04/15/2006 - "Second, AhR null mice were treated with ETA receptor antagonist, BQ-123 (100 nmol/kg/day), for 7, 28, or 58 days and blood pressure, cardiac fibrosis, and cardiac hypertrophy assessed, respectively. "
|3.||Endothelin Receptors (Endothelin Receptor)
|4.||Endothelin A Receptor
|5.||Endothelin-1 (Endothelin 1)
|2.||Heart Transplantation (Grafting, Heart)
|5.||Angioplasty (Angioplasty, Transluminal)