nartograstim

a mutein of recombinant human G-CSF

Also Known As:

G-CSF, N-Met-Ala(1)-Thr(3)-Tyr(4)-Arg(5)-Ser(17)-; G-CSF, N-methionyl-alanyl(1)-threonyl(3)-tyrosyl(4)-arginyl(5)-seryl(17)-; KW 2228; KW-2228; N-L-methionyl-1-L-alanine-3-L-threonine-4-L-tyrosine-5-L-arginine-17-L-serine-CSF; granulocyte-colony-stimulating factor, N-Met-Ala(1)-Thr(3)-Tyr(4)-Arg(5)-Ser(17)-; Colony-stimulating factor (human clone 1034), 1-(N-L-methionyl-L-alanine)-3-L-threonine-4-L-tyrosine-5-L-arginine-17-L-serine-

Networked: 17 relevant articles (5 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ando, Takashi: 1 article (01/2021)
2.	Barazzone, Giovana C: 1 article (01/2021)
3.	Borelli, Primavera: 1 article (01/2021)
4.	Carvalho, Eneas: 1 article (01/2021)
5.	Eguia, Fara A P: 1 article (01/2021)
6.	Gonçalves, Viviane M: 1 article (01/2021)
7.	Ho, Paulo Lee: 1 article (01/2021)
8.	Iguchi, Toyotaka: 1 article (01/2021)
9.	Ishiguro, Chieko: 1 article (01/2021)
10.	Kajiyama, Kazuhiro: 1 article (01/2021)

Related Diseases

1.	Infections 01/01/1992 - "KW-2228 displayed excellent protective potency dose-dependently against the infection with P. " 01/01/1992 - "We concluded that combination therapies of KW-2228 with various chemotherapeutic drugs in experimental infections in mice showed that it should be effective in normal and immunosuppressed host. " 01/01/1992 - "These data show the possibility that prophylactic therapy with KW-2228 may augment the host defense of immunocompromised patients to infections. " 01/01/1992 - "[Protective effect of KW-2228 in a systemic infection model of CPA-treated tumor-bearing mice]." 01/01/1992 - "These results of our laboratory studies suggest that KW-2228 in combination with antibiotics would be useful in the clinical treatment of microbial infections. "
2.	Neutropenia 01/01/2021 - "• Nartograstim biological activity was demonstrated in mice using a neutropenia model." 02/01/2000 - "Among 98 eligible patients evaluated for neutrophil recovery, a markedly reduced duration of neutropenia was observed during each course in the KW-2228 treated group. " 02/01/1993 - "These results indicated that KW-2228 is a useful drug to treat neutropenia in children." 01/01/2000 - "Lenograstim (2 micrograms/kg) was more effective in shortening the duration of neutropenia than nartograstim (1 microgram/kg) (3.8 days vs. 5.0 days, p < 0.05, the number of days for the neutrophil count to reach 5 x 10(9)/l from nadir). " 02/01/2000 - "These results demonstrated that KW-2228 is effective and safe, and has a significant effect on the acceleration of neutrophil recovery in patients with neutropenia induced by chemotherapy for multiple myeloma, and is useful for the completion of chemotherapy regimens."
3.	Multiple Myeloma 02/01/2000 - "These results demonstrated that KW-2228 is effective and safe, and has a significant effect on the acceleration of neutrophil recovery in patients with neutropenia induced by chemotherapy for multiple myeloma, and is useful for the completion of chemotherapy regimens." 02/01/2000 - "A randomized controlled study of patients with multiple myeloma was performed to evaluate the efficacy and safety of recombinant human granulocyte colony-stimulating factor (rhG-CSF:KW-2228) in treating neutropenia induced by chemotherapy, and its influence on the dose intensity of, and response rate to, chemotherapy. "
4.	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/01/2000 - "Using a standard dose of G-CSF, we conducted a randomized, crossover trial that compared the efficacy of two kinds of G-CSF, glycosylated [lenograstim (2 micrograms/kg)] and mutated [nartograstim (1 microgram/kg)], on PBSC mobilization in 10 patients with non-Hodgkin's lymphoma after biweekly CHOP chemotherapy. "
5.	Leukopenia 01/01/1992 - "In this paper, we investigated protective effects of KW-2228 against systemic infections caused by Klebsiella pneumoniae in mice with leukopenia induced by the administration of cyclophosphamide. " 06/01/2001 - "However, these taxane compounds induced neutropenia and leukopenia, which may be reversed by G-CSF (Nartograstim). " 06/01/2001 - "[Effect of G-CSF (nartograstim) on neutropenia (leukopenia) induced by taxane in metastatic breast cancer--time-course changes in neutrophil and leukocyte counts]."

Related Drugs and Biologics

1.	Granulocyte Colony-Stimulating Factor (G-CSF)
2.	Anti-Bacterial Agents (Antibiotics)
3.	Lenograstim
4.	Cyclophosphamide (Cytoxan)
5.	Carboplatin (JM8)
6.	Irinotecan (Camptosar)
7.	Docetaxel (Taxotere)
8.	Ceftazidime (Fortum)
9.	Cefmetazole (Cefmetazole Sodium)
10.	Pancreatic Elastase (Elastase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Transplantation
4.	Subcutaneous Injections