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trefoil factor

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member of trefoil peptide family; from rat intestinal villus epithelial cells; has homology with (pancreatic) porcine, mouse & human trefoil peptides; 81 amino acid residues; amino acid sequence in first source; RefSeq NM_053844 (rat), NM_005423 (human); do not confuse with SML1 protein

Also Known As:

ITF protein; SP, rat gastrointestinal tract; TFF2 protein; TFF2 protein, human; Tff2 protein, rat; human SML1/hSP; human spasmolytic protein SML1; human spasmolytic protein hSP/SML1; intestinal trefoil factor; spasmolytic polypeptide, rat; spasmolytic polypeptide, rat gastric mucous cells; spasmolytic protein 1, rat; trefoil factor 2 (spasmolytic protein 1), human; trefoil factor 2, rat

Networked: 161 relevant articles (7 outcomes, 22 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Peptides: 16229
  - trefoil factor: 161

Experts

1.	May, Felicity E B: 7 articles (03/2009 - 01/2003)
2.	Westley, Bruce R: 6 articles (03/2009 - 01/2003)
3.	Takano, Toru: 5 articles (03/2009 - 01/2004)
4.	Gespach, Christian: 5 articles (09/2008 - 01/2003)
5.	Wang, Timothy C: 4 articles (08/2009 - 08/2004)
6.	Wang, Lin: 4 articles (12/2008 - 05/2005)
7.	Attoub, Samir: 4 articles (09/2008 - 01/2003)
8.	Fox, James G: 3 articles (08/2009 - 08/2004)
9.	Zhang, Yong: 3 articles (12/2008 - 05/2005)
10.	Li, Lin: 3 articles (10/2008 - 01/2005)

Related Diseases

1.	Colitis 08/01/2006 - "Trefoil factor (TFF) producer strains have also been shown to be very effective in the treatment of acute colitis. " 01/01/2005 - "In order to investigate the protective effects of intestinal trefoil factor (ITF) on colonic mucosa in experimental colitis of rats, ITF was detected by RT-PCR and immunohistochemistry at different time points. " 01/01/2005 - "Effects of intestinal trefoil, factor on colonic mucosa in experimental colitis of rats." 10/01/2004 - "Furthermore, colons with constitutive activation of HIF displayed increased expression levels of HIF-1-regulated barrier-protective genes (multidrug resistance gene-1, intestinal trefoil factor, CD73), resulting in attenuated loss of barrier during colitis in vivo. " 05/01/1999 - "In addition, endogenous concentrations of rat TFF2 and TFF3 (intestinal trefoil factor) were increased in the active phase of colitis and were reduced to basal levels by hTFF2 treatment. " Order ALL the reference details at left...
2.	Wounds and Injuries (Trauma) 10/01/2006 - "[Protective effects of recombinant intestinal trefoil factor against intestinal injuries induced by endotoxin in young rats]" 05/09/2008 - "Intestinal trefoil factor/TFF3 promotes re-epithelialization of corneal wounds." 01/18/2000 - "Intestinal trefoil factor (ITF) is an essential regulator of colonic epithelial restitution, the rapid migration of colonocytes over mucosal wounds. " 03/01/2004 - "Intestinal trefoil factor improved intestinal epithelial cell viability and wound repair after chemotherapy exposure in vitro. " 09/01/2005 - "[Association of trefoil factor 1 expression with gastric mucosa injuries and gastric cancer]" Order ALL the reference details at left...
3.	Mucositis 03/01/2004 - "CONCLUSIONS: These studies suggest that intestinal trefoil factor is involved in protection against and recovery from intestinal mucositis induced by radiation and chemotherapy." 03/01/2004 - "Intestinal trefoil factor-deficient mice (intestinal trefoil factor(-/-)) were more susceptible to chemotherapy- and radiation-induced mucositis. " 03/01/2004 - "Oral recombinant intestinal trefoil factor reduced the severity of both chemotherapy-induced and chemotherapy/radiotherapy-induced intestinal mucositis. " 10/01/2009 - "Intestinal trefoil factor (ITF), a member of trefoil factor family (TFF) domain peptides, was proved to be very effective in prevention and healing of acute dextran sodium sulfate-induced colitis, and was also involved in protection against and recovery from intestinal mucositis induced by radiation and chemotherapy. " Order ALL the reference details at left...
4.	Stomatitis 09/10/2009 - "PURPOSE: This study evaluated the safety and efficacy of recombinant human intestinal trefoil factor (rhITF) administered as topical oral spray for prevention and treatment of chemotherapy-induced oral mucositis (OM). " 09/10/2009 - "Phase II, randomized, double-blind, placebo-controlled study of recombinant human intestinal trefoil factor oral spray for prevention of oral mucositis in patients with colorectal cancer who are receiving fluorouracil-based chemotherapy." Order ALL the reference details at left...
5.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 08/01/2008 - "Trefoil factor family (TFF) peptides maintain and repair the gastrointestinal mucosa and are aberrantly expressed in human and rodent inflammatory bowel disease and carcinomas, diseases common in dogs and cats. " 01/01/2002 - "CONCLUSIONS: Down-regulation of intestinal trefoil factor TFF3 due to transcriptional repression by IL1beta through NF-kappaB as well as by IL6 through C/EBPbeta activation in vitro may reflect the situation in vivo and may contribute to ulceration and decreased wound healing during inflammatory bowel disease. " 03/01/2006 - "When compared with the T group, the OS group showed decreased anorexia and body weight loss; reduced bowel wall thickening and longitudinal extension of necrotic lesions; downregulated colonic expression of interleukin 1beta, inducible nitric oxide synthase, cyclooxygenase 2, and mucin 3; and increased trefoil factor 3. Thus, goat milk oligosaccharides have anti-inflammatory effects in rats with experimental colitis and may be useful in the management of inflammatory bowel disease." Order ALL the reference details at left...

Related Drugs and Biologics

1.	trefoil factor
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Interleukin-1beta (Interleukin 1 beta)
4.	Amine Oxidase (Copper-Containing)
5.	Peptides
6.	Cyclooxygenase 2 (Cyclooxygenase-2)
7.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
8.	Dextrans (Dextran)
9.	sodium sulfate (sodium bisulfate)
10.	Mucin-3

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Cell Transplantation
4.	Enema (Enemas)

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