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bothropstoxin II

a phospholipase A2 from the venom of Bothrops jararacussu

Also Known As:

BJUPLA2; BthTX-II

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Giglio, J R: 3 articles (01/2014 - 08/2004)
2.	Goulart, Luiz Ricardo: 2 articles (01/2022 - 08/2019)
3.	Lopes, Daiana Silva: 2 articles (01/2022 - 08/2019)
4.	Zóia, Mariana Alves Pereira: 2 articles (01/2022 - 08/2019)
5.	Soares, A M: 2 articles (01/2014 - 08/2004)
6.	Giglio, José R: 2 articles (12/2005 - 09/2005)
7.	Correia, Lucas Ian Veloso: 1 article (01/2022)
8.	Fonseca, Belchiolina Beatriz: 1 article (01/2022)
9.	Polloni, Lorena: 1 article (01/2022)
10.	Saito, Natieli: 1 article (01/2022)

Related Diseases

1.	Edema (Dropsy) 08/01/2004 - "In this study, we demonstrate that CA significantly inhibits the edema induced by BthTX-I (23% inhibition), BthTX-II (27%), PrTX-I (25%), PrTX-III (35%) and MjTX-II (10%) on the mouse paw. " 01/01/2014 - "Alkylation reduced BthTX-II activity by 50% while this process abolished the catalytic and myotoxic activities of BthTX-I, while reducing its edema-inducing activity by about 50%. " 09/01/2005 - "RA inhibited the edema and myotoxic activity induced by the basic PLA2s BthTX-I and BthTX-II. It was, however, less efficient to inhibit the PLA2 activity of BthTX-II and, still less, the PLA2 and edema-inducing activities of the acidic isoform BthA-I-PLA2 from the same venom, showing therefore a higher inhibitory activity upon basic PLA2s. "
2.	Triple Negative Breast Neoplasms 01/01/2022 - "BthTx-II was also able to inhibit the sprouting angiogenic process, by the ex vivo germination assay of the aortic ring; in addition, this toxin inhibited the migration and proliferation of HUVEC in co-culture with triple-negative breast cancer cells (e.g., MDA-MB-231 cells). " 08/15/2019 - "In conclusion, these results showed that BthTX-II displays antitumor and antimetastatic effects on MDA-MB-231 cells and may be useful for the development of new approaches and therapeutic strategies to manage triple negative breast cancer." 01/01/2022 - "A New Approach to Inhibiting Triple-Negative Breast Cancer: In Vitro, Ex Vivo and In Vivo Antiangiogenic Effect of BthTx-II, a PLA2-Asp-49 from Bothrops jararacussu Venom." 08/15/2019 - "This work shows the antitumor and antimetastatic effects of BthTX-II, an Asp-49 PLA2 from Bothrops jararacussu venom, on MDA-MB-231 human triple negative breast cancer cells. "
3.	Necrosis 01/01/2005 - "Histological analysis of soleus muscle after incubation with AE (400 microg/ml, 1 h) did not reveal any change in muscle fibers, but severe necrosis induced by BV or toxins (20 microg/ml) was clearly in evidence, and decreased significantly when soleus muscle was protected by AE. This protection was also observed when AE was administered 1 h after BV or BthTX-I, but not after BthTX-II. AE did not inhibit the catalytic PLA2 activity of BthTX-II or BV and did not change the PAGE pattern of BV, BthTX-I or BthTX-II. In vivo assays were performed in 100-g rats and maximal CK release was attained at a dose of 100 microg of BV, 3 h after injection. " 12/15/2005 - "The lung myeloperoxidase and serum amylase were also increased for all groups, although the Naja mocambique mocambique venom PLA(2) induced higher lung myeloperoxidase and serum amylase values, compared with piratoxin-I and/or bothropstoxin-II. Histopathology of pancreas and lungs in piratoxin-I-injected rats showed interstitial oedema in both tissues, and neutrophil infiltration with acinar cell necrosis in pancreas. "
4.	Snake Bites (Snake Bite) 05/01/2015 - "jararacussu venom and its phospholipase toxins, BthTX-I and BthTX-II. Thus, fucosylated chondroitin sulfate is a new polyanion with potential to be used as an adjuvant in the treatment of snakebites in the future."
5.	Neoplasms (Cancer) 01/01/2022 - "In this sense, the present work reports the inhibition of tumor angiogenesis induced by Asp-49 BthTX-II using in vitro, ex vivo and in vivo approaches. " 01/01/2022 - "Finally, in vivo tumor suppression and anti-angiogenic activities were analyzed using MDA-MB-231 cells with Matrigel injected into the chorioallantoic membrane of chicken embryo (CAM) for 7 days treatment with BthTx-II, showing a considerable reduction in vessel caliber, on the size and weight of tumors. " 01/01/2022 - "Together, these results suggest an important antiangiogenic and antitumor role for BthTx-II, as a potential prototype for the development of new tools and antitumor drugs in cancer therapy."

Related Drugs and Biologics

1.	bothropstoxin
2.	Venoms
3.	Neutralizing Antibodies
4.	Protein Isoforms (Isoforms)
5.	Phospholipases (Phospholipase)
6.	Neurotoxins
7.	Peroxidase (Myeloperoxidase)
8.	Antineoplastic Agents (Antineoplastics)
9.	Amylases
10.	fucosylated chondroitin sulfate

Related Therapies and Procedures

1.	Therapeutics