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U 78518F
a member of the lazaroid family of 21-amino steroid derivatives; RN given is for HCl
Also Known As:
2H-1-benzopyran-6-ol,2-((4-(3-(ethylamino)-2-pyridinyl)-1-piperazinyl)methyl)-3,4-dihydro-2,5,7,8-tetramethyl-(Z)-2-butenedioate; U 78518E; U-78518E; U-78518F; U78518F
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Ethylamines: 5
U 78518F: 3
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
U 78518F: 3
Piperazines: 26
U 78518F: 3
Related Diseases
1.
Acute Lung Injury
05/01/1993 - "
We examined the effect of intravenous U-78518F on acute lung injury in septic guinea pigs over 8 h.
"
05/01/1993 - "
Attenuation of acute lung injury and oxygen radical production by the 21-aminosteroid, U-78518F.
"
2.
Type 1 Diabetes Mellitus (Autoimmune Diabetes)
04/01/1993 - "
We examined the effects of a potent antioxidant compound, U78518F, on the incidence of diabetes and pancreatic islet infiltration with lymphocytes and monocytes (insulitis) in the non-obese diabetic (NOD) mouse, an animal model for human IDDM.
"
3.
Breast Neoplasms (Breast Cancer)
05/30/1992 - "
The antiproliferative properties of three 21-aminosteroid antioxidants (lazaroids), 21-[4-[5,6-bis(diethylamino)-2-pyridinyl]-1- piperazinyl]-16 alpha-methylpregna-1,4,9(11)triene-3,20-dione, hydrochloride (U74500A), 21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piper- azinyl]-pregna-1,4,9(11)-triene-3,20-dione, monomethanesulfonate (U74389F), 2H-1-benzopyran-6-ol, 2-[[4-[3-(ethylamino)-2-pyridinyl]-1-piperzinyl]methyl]-3,4- dihydro-2,5,7,8-tetramethyl-, (Z)-2-buten dioate (U78518F), on human breast cancer cells are described.
"
Related Drugs and Biologics
1.
Antioxidants
2.
Reactive Oxygen Species (Oxygen Radicals)
3.
U 74389F
4.
U 74500A