|1.||Jackson, Peter K: 5 articles (04/2008 - 07/2004)|
|2.||Teodoro, Jose G: 3 articles (06/2011 - 04/2005)|
|3.||Lehman, Norman L: 3 articles (04/2008 - 07/2006)|
|4.||Roychoudhury, Susanta: 2 articles (01/2015 - 01/2007)|
|5.||Wäsch, Ralph: 2 articles (12/2013 - 01/2005)|
|6.||Spector, Deborah H: 2 articles (10/2010 - 01/2008)|
|7.||Tran, Karen: 2 articles (10/2010 - 01/2008)|
|8.||Moyret-Lalle, Caroline: 2 articles (10/2009 - 03/2003)|
|9.||Lim, Dae-Sik: 2 articles (03/2009 - 02/2005)|
|10.||Song, Min Sup: 2 articles (03/2009 - 02/2005)|
02/01/2014 - "Cdh1, a coactivator of the anaphase-promoting complex (APC), is a potential tumor suppressor. "
03/01/2012 - "Although cancer cells may display different responses to these treatments, recent data suggest that targeting mitotic exit by inhibiting the anaphase-promoting complex generates metaphase cells that invariably die in mitosis. "
03/15/2009 - "The tumor suppressor RASSF1A controls mitotic progression by regulating anaphase-promoting complex (APC)-Cdc20 activity and microtubule stability, but the mechanism by which this action is regulated has not been previously established. "
07/01/2007 - "It has been reported that the RASSF1A tumor suppressor protein controls mitotic progression by binding to and inhibiting Cdc20, an activator of the anaphase-promoting complex. "
07/01/2007 - "The tumor suppressor RASSF1A does not interact with Cdc20, an activator of the anaphase-promoting complex."
04/01/2005 - "The anaphase-promoting complex (APC) is required for mitotic progression and genomic stability. "
02/01/2012 - "Anaphase promoting complex cofactor Cdh1 plays a critical role in tumor suppression and genomic stability in cancer. "
01/06/2005 - "Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells."
10/01/2004 - "Defects in anaphase-promoting complex (APC) activity, which regulates mitotic progression and chromatin assembly, results in genomic instability, a hallmark of premature aging and cancer. "
08/15/2005 - "The spindle checkpoint maintains genome stability by inhibiting Cdc20-mediated activation of the anaphase promoting complex/cyclosome (APC/C) until all the chromosomes correctly align on the microtubule spindle apparatus via their kinetochores. "
01/01/2014 - "The spindle assembly checkpoint (SAC) prevents aneuploidy by coupling anaphase onset, through anaphase-promoting complex (APC) activation, with chromosome attachment to spindle microtubules. "
12/01/2012 - "The mitotic checkpoint is an important mechanism that prevents aneuploidy by restraining the activity of the anaphase-promoting complex (APC). "
01/01/2007 - "Thus, abnormalities in the cellular level of Cdc20 may deregulate the timing of anaphase promoting complex (APC/C) in promoting premature anaphase, which often results in aneuploidy in the tumor cells."
03/17/2014 - "In this paper, we find that MAPK and Cdk1 play compensatory roles to suppress the anaphase-promoting complex/cyclosome (APC/C) activity early in prometaphase, thereby allowing accumulation of APC/C substrates essential for meiosis I. Furthermore, inhibition of MAPK around the onset of APC/C activity at the transition from meiosis I to meiosis II led to accelerated completion of meiosis I and an increase in aneuploidy at metaphase II. These effects appear to be mediated via a Cdk1/MAPK-dependent stabilization of the spindle assembly checkpoint, which when inhibited leads to increased APC/C activity. "
11/01/2011 - "The spindle checkpoint senses unattached or improperly attached kinetochores during mitosis, inhibits the anaphase-promoting complex or cyclosome (APC/C), and delays anaphase onset to prevent aneuploidy. "
10/01/2010 - "Infection of quiescent cells by human cytomegalovirus (HCMV) elicits severe cell cycle deregulation, resulting in a G(1)/S arrest, which can be partly attributed to the inactivation of the anaphase-promoting complex (APC). "
06/01/2011 - "Targeting the anaphase promoting complex: common pathways for viral infection and cancer therapy."
01/01/2008 - "Cell cycle dysregulation upon human cytomegalovirus (HCMV) infection of human fibroblasts is associated with the inactivation of the anaphase-promoting complex (APC), a multisubunit E3 ubiquitin ligase, and accumulation of its substrates. "
01/01/2014 - "Functional categories including cytoplasmic ribosomal proteins, jasmonic acid biosynthesis and anaphase promoting complex/cyclosomes had a significant excess in upregulated genes, whereas spliceosomal snRNP complexes and the shikimate pathway had significantly more down-regulated genes, suggesting that these pathways were activated or shut-down in response to the virus infection. "
|5.||Chromosomal Instability (Chromosome Stability)
01/01/2015 - "Deregulation of Rb-E2F1 axis causes chromosomal instability by engaging the transactivation function of Cdc20-anaphase-promoting complex/cyclosome."
07/01/2008 - "Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability."
01/01/2015 - "We conclude that excess E2F1 due to Rb inactivation recruits the complex of Cdc20 and the anaphase-promoting complex/cyclosome (Cdc20-APC/C) to deregulate the expression of UBCH10, leading to chromosomal instability in cancer cells. "
|4.||Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
|5.||Proteins (Proteins, Gene)
|7.||Type I Keratins (Type I Keratin)
|10.||Proteasome Endopeptidase Complex (Proteasome)