Cisplatin FDA Link Generic

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.

Also Known As:

Platino; cis-Platinum; Biocisplatinum; Dichlorodiammineplatinum; NSC-119875; Platidiam; Platinol; cis-Diamminedichloroplatinum; Diamminodichloride, Platinum; cis Diamminedichloroplatinum; cis Platinum; Platinum Diamminodichloride; cis-Diamminedichloroplatinum(II); cis-Dichlorodiammineplatinum(II); Platinum, diamminedichloro-, (SP-4-2)-

Pharmalogical Action Categories:

Antineoplastic Agents
Cross-Linking Reagents
Radiation-Sensitizing Agents

Inorganic Chemicals: 9
- Platinum Compounds: 758
  - Cisplatin: 46373
- Nitrogen Compounds: 67
  - Cisplatin: 46373
- Chlorine Compounds: 8
  - Cisplatin: 46373

cisplatin-guanosine adduct

Bio-Agent Context: Research Results