|1.||Hu, Lihong: 4 articles (02/2015 - 01/2011)|
|2.||Kadota, Shigetoshi: 4 articles (01/2014 - 02/2006)|
|3.||Awale, Suresh: 4 articles (01/2014 - 02/2006)|
|4.||Tezuka, Yasuhiro: 4 articles (01/2014 - 02/2006)|
|5.||Shen, Xu: 3 articles (10/2014 - 01/2011)|
|6.||Chen, Jing: 3 articles (10/2014 - 01/2011)|
|7.||Esumi, Hiroyasu: 3 articles (01/2014 - 02/2006)|
|8.||Kim, Dong-Hyun: 3 articles (05/2013 - 01/2011)|
|9.||Nho, Chu Won: 3 articles (08/2011 - 12/2007)|
|10.||Kim, Chul Young: 3 articles (08/2011 - 12/2007)|
05/15/2013 - "Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages."
08/01/2015 - "Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stress and Inflammation in a Mouse Model via Suppression of MAPK, HO-1, and iNOS Signaling."
12/01/2013 - "Arctigenin, a lignan extract from Arctium lappa (L.), exhibits anti-inflammation, antioxidation, vasodilator effects, etc. However, the effects of arctigenin on bronchus relaxation are not well investigated. "
04/01/2013 - "The phenylpropanoid dibenzylbutyrolactone lignan arctigenin, a key component found in Arctium lappa, or burdock, has been reported with a variety of therapeutic effects including anticancer, anti-inflammation, and antivirus effects. "
03/01/2008 - "Results from our in vivo and in vitro experiments clearly indicate that arctigenin reduced (i) viral load and viral replication within the brain, (ii) neuronal death and (iii) secondary inflammation and oxidative stress resulting from microglial activation, thereby suggesting its potential for treating JE. "
08/15/2015 - "In conclusion, arctigenin ameliorates colitis through down-regulating the differentiation of Th1 and Th17 cells via mTORC1 pathway. "
08/15/2015 - "As Th1 and Th17 cells play a crucial role in the pathogenesis of IBD, the present study addressed whether and how arctigenin exerted anti-colitis efficacy by interfering with the differentiation and activation of Th1/Th17 cells. "
08/15/2015 - "Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17 cells via an mTORC1-dependent pathway."
05/15/2013 - "Based on these findings, arctigenin may ameliorate inflammatory diseases, such as colitis, by inhibiting PI3K and polarizing M1 macrophages to M2-like macrophages."
08/15/2015 - "In DSS-induced mice, the inhibition of Th1/Th17 responses and anti-colitis effect of arctigenin were abrogated by leucine treatment. "
01/01/2011 - "Mice treadmill based in vivo assay further indicated that administration of arctigenin improved efficiently mice endurance as reflected by the increased fatigue time and distance, and potently enhanced mitochondrial biogenesis and fatty acid oxidation (FAO) related genes expression in muscle tissues. "
10/01/2014 - "In the present study, we investigated the antioxidation and anti-fatigue effects of arctigenin in rats. "
10/01/2014 - "Arctigenin efficiently enhances rat swimming endurance by elevation of the antioxidant capacity of the skeletal muscles, which has thereby highlighted the potential of this natural product as an antioxidant in the treatment of fatigue and related diseases."
|4.||Memory Disorders (Memory Loss)
09/01/2011 - "Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice."
09/01/2011 - "On the basis of these findings, arctigenin may ameliorate memory deficits by inhibiting AChE."
09/01/2011 - "Arctigenin also significantly reversed scopolamine-induced memory deficits in the Y-maze and Morris water maze tests. "
09/01/2011 - "Arctigenin at doses of 30 and 60 mg/kg (p. o.) potently reversed scopolamine-induced memory deficits by 62 % and 73 %, respectively, in a passive avoidance test. "
01/01/2013 - "Arctigenin (Arc) has been shown to act on scopolamine-induced memory deficit mice and to provide a neuroprotective effect on cultured cortical neurons from glutamate-induced neurodegeneration through mechanisms not completely defined. "
|5.||Alzheimer Disease (Alzheimer's Disease)
08/07/2013 - "Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance."
01/01/2012 - "Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignin isolated from certain plants, has shown anti-inflammatory activity against diabetes and Alzheimer's disease. "
|3.||Amyloid (Amyloid Fibrils)
|8.||STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)
|2.||Drug Therapy (Chemotherapy)