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RP 67580

structure given in first source; RP 68651 is the inactive (3aS,7aS)-isomer; substance P antagonist
Also Known As:
7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one; RP 68651; RP-67580; RP-68651; 4H-Isoindol-4-one, octahydro-2-(1-imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenyl-, (3aR-cis)-
Networked: 25 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Wang, Donna H: 3 articles (12/2012 - 09/2007)
2. Zhong, Beihua: 2 articles (08/2008 - 09/2007)
3. Wang, Youping: 1 article (12/2012)
4. Gaudreau, Pierrette: 1 article (01/2012)
5. Bogo, Maurício Reis: 1 article (01/2012)
6. Couture, Réjean: 1 article (01/2012)
7. Lahjouji, Karim: 1 article (01/2012)
8. Talbot, Sébastien: 1 article (01/2012)
9. Dias, Jenny Pena: 1 article (01/2012)
10. Campos, Maria Martha: 1 article (01/2012)

Related Diseases

1. Pain (Aches)
2. Neurogenic Inflammation
3. Vomiting
02/05/1999 - "(P < 0.05) and RP 67580 produced a significant reduction of motion-induced emesis at 10 mg/kg, i.p. "
02/05/1999 - "RP 67580 and FK 888 failed to antagonize copper sulphate-induced emesis but CP-122,721 and CP-99,994 were active yielding ID50 values of 2.2 and 3.0 mg/kg, i.p., respectively. "
02/05/1999 - "A 30 min intraperitoneal pre-treatment with CP-122,721, CP-99,994, RP 67580 and FK 888 significantly (P < 0.05) antagonized nicotine-induced emesis with ID50 values of 2.1, 2.3, 13.5 and 19.2 mg/kg, respectively CP-100,263, the less active enantiomer of CP-99,994, was inactive at doses up to 10 mg/kg. Infusion of GR 82334, CP-122,721, CP-99,994 and FK 888 into the dorsal vagal complex of the hindbrain also antagonized nicotine-induced emesis yielding ID50 values of 1.1, 3.0, 3.3 and 58.0 microg/dorsal vagal complex, respectively RP 67580 and CP-100,263 were inactive. "
02/05/1999 - "The anti-emetic potential of CP-122,721 ((+)-2S,3S)-3-(2-methoxy-5-trifluoromethoxybenzyl)amino-2-phenylpi peridine), CP-99,994 ((+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine), CP-100,263 ((-)-(2R,3R)-3-(2-methoxybenzylamino)-2-phenylpiperidine), RP 67580 ((3R, 7aR)-7,7-diphenyl-2-[1-imino-2-(2-methoxyphenyl)ethyl] po-hydroisoindol-4-one), FK 888 (N2-[(4R)-4-hydroxy-1-(1-methyl-1H-in-dole-3-yl)carbonyl-L-propyl] -N-methyl-N-phenylmethyl-1-3-(2-naphthyl)-alaninamide) and GR 82334 ([D-Pro9[spiro-g-lactam]Leu10]-physalaemin-(1-11)) was investigated to inhibit nicotine (5 mg/kg, s.c.)-, copper sulphate pentahydrate (120 mg/kg, intragastric)- and motion (4 cm horizontal displacement at 1 Hz for 5 min)-induced emesis in Suncus murinus. "
4. Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
5. Hyperalgesia

Related Drugs and Biologics

1. Neurokinin-1 Receptors (Neurokinin 1 Receptor)
2. Tachykinin Receptors (Tachykinin Receptor)
3. Formaldehyde (Formol)
4. SR 48968 (saredutant)
5. Neurokinin-2 Receptors (Neurokinin 2 Receptor)
6. Dihydrotachysterol (AT 10)
7. Substance P
8. Tachykinins
9. N-Methylaspartate (NMDA)
10. 3- (2- methoxybenzylamino)- 2- phenylpiperidine