FPL 64176

an activator of L-type calcium channels; structure given in first source

Also Known As:

FPL-64176; FPL64176; methyl 2,5-dimethyl-4-(2-(phenylmethyl)benzoyl)-1H-pyrrole-3-carboxylate; 1H-Pyrrole-3-carboxylic acid, 2,5-dimethyl-4-(2-(phenylmethyl)benzoyl)-, methyl ester

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - FPL 64176: 8

Experts

1.	Darmani, Nissar A: 3 articles (01/2017 - 01/2014)
2.	Zhong, Weixia: 3 articles (01/2017 - 01/2014)
3.	Chebolu, Seetha: 2 articles (05/2014 - 01/2014)
4.	Jinnah, H A: 2 articles (11/2003 - 05/2000)
5.	Chan, John D: 1 article (12/2019)
6.	McCusker, Paul: 1 article (12/2019)
7.	Lee, Albert S: 1 article (01/2017)
8.	Picca, Andrew J: 1 article (01/2017)
9.	Alkam, Tursun: 1 article (01/2014)
10.	Vaezi, Mariam: 1 article (01/2014)

Related Diseases

1.	Vomiting 01/05/2014 - "Administration of FPL 64176 did cause vomiting in the least shrew in a dose-dependent fashion. " 01/01/2017 - "Our findings demonstrate that application of the L-type Ca2+ channel (LTCC) agonist FPL 64176 and the intracellular Ca2+ mobilizing agent thapsigargin (a sarco/endoplasmic reticulum Ca2+-ATPase inhibitor) cause vomiting in the least shrew. " 01/05/2014 - "We envisaged that L-type calcium agonists such as FPL 64176 should cause vomiting and corresponding antagonists such as nifedipine would behave as broad-spectrum antiemetics. " 05/01/2014 - "Subcutaneous (s.c.) administration of amlodipine (0.5-10mg/kg) attenuated in a dose-dependent and potent manner both the frequency and percentage of shrews vomiting in response to intraperitoneal (i.p.) administration of FPL 64176 (10mg/kg), 5-HT (5mg/kg), 2-Me-5-HT (5mg/kg), apomorphine (2mg/kg), quinpirole (2mg/kg), pilocarpine (2mg/kg), McN-A343 (2mg/kg), or GR73632 (5mg/kg). "
2.	Dystonia (Limb Dystonia) 11/01/2003 - "In rodents, administration of the L-type calcium channel activators, +/-Bay K 8644 and FPL 64176, causes an unusual neurobehavioral syndrome that includes dystonia and self-injurious biting. " 05/01/2000 - "Systemic administration of the L-type calcium channel agonists +/-Bay K 8644 or FPL 64176 causes a characteristic pattern of motor dysfunction in normal C57BL/6J mice that resembles generalized dystonia. "
3.	Torsades de Pointes (Torsade de Pointes) 09/01/2009 - "Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts."
4.	Paralysis (Palsy) 12/01/2019 - "Unlike DHPs, FPL-64176 evokes rapid and sustained contractile paralysis of adult Schistosoma mansoni reminiscent of the anthelmintic praziquantel. "
5.	Ischemia 02/01/2013 - "Moreover, similar to Bay K8644, FPL 64176, another potent LTCC agonist, extends the window of intervention against neuronal injury in an in vitro model of ischemia. "

Related Drugs and Biologics

1.	Methyl ester 1,4- dihydro- 2,6- dimethyl- 5- nitro- 4- (2- (trifluoromethyl)phenyl)- 3-Pyridinecarboxylic acid
2.	L-Type Calcium Channels (Dihydropyridine Receptor)
3.	Sarcoplasmic Reticulum Calcium-Transporting ATPases
4.	Thapsigargin
5.	Quinpirole
6.	Amlodipine (Norvasc)
7.	Serotonin (5 Hydroxytryptamine)
8.	Praziquantel (Biltricide)
9.	Pilocarpine (Ocusert)
10.	Nifedipine (Adalat)