GP 7

structure given in first source

Also Known As:

4-(4''-(2'',2'',6'',6''-tetramethyl-1''-piperidinyloxy)amino)-4'-demethylepipodophyllotoxin; GP-7; GP7 compound; 1-Piperidinyloxy, 4-((5,5a,6,8,8a,9-hexahydro-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxofuro(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-5-yl)amino)-2,2,6,6-tetramethyl-, (5alpha,5abeta,8aalpha,9beta)-

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Calabrese, Daniela: 1 article (01/2022)
2.	Coffin, Benoit: 1 article (01/2022)
3.	Duboc, Henri: 1 article (01/2022)
4.	Mariano, Germano: 1 article (01/2022)
5.	Moszkowicz, David: 1 article (01/2022)
6.	Soliman, Heithem: 1 article (01/2022)

Related Diseases

1.	Transfusion Reaction 02/15/1994 - "Using immunobead techniques we found (1) anti-GPs in 85% of sera; (2) IgA and IgG Abs each in 68%, together in 51%; (3) IgM agglutinins in 15%, always with another Ab class; (4) GP Ib/IX, IIb/IIIa, IV, and Ia/IIa targets in 83%, 81%, 38%, and 28% of cases, respectively; (5) 93% of positive sera reactive with more than one GP; but GP IV or Ia/IIa never the sole target; (6) Abs against cytosolic epitopes on one or more of GPs IIIa, Ib alpha, and IIb beta in 66% of sera, always accompanied by Abs against exosolic epitopes of the same or a different GP; (7) autoAbs against cytosolic GP epitopes in 38% of 16 patients recovered from posttransfusion purpura and drug purpura; and (8) evidence that serum ITP Abs, often high-titered, saturate platelets less than alloAbs against the same GPs. "
2.	Purpura 02/15/1994 - "Using immunobead techniques we found (1) anti-GPs in 85% of sera; (2) IgA and IgG Abs each in 68%, together in 51%; (3) IgM agglutinins in 15%, always with another Ab class; (4) GP Ib/IX, IIb/IIIa, IV, and Ia/IIa targets in 83%, 81%, 38%, and 28% of cases, respectively; (5) 93% of positive sera reactive with more than one GP; but GP IV or Ia/IIa never the sole target; (6) Abs against cytosolic epitopes on one or more of GPs IIIa, Ib alpha, and IIb beta in 66% of sera, always accompanied by Abs against exosolic epitopes of the same or a different GP; (7) autoAbs against cytosolic GP epitopes in 38% of 16 patients recovered from posttransfusion purpura and drug purpura; and (8) evidence that serum ITP Abs, often high-titered, saturate platelets less than alloAbs against the same GPs. "
3.	Sarcoma 180 05/01/1995 - "GP-7 disappeared more slowly from the plasma of mice bearing sarcoma 180, distributed extensively over the tissues and was partially excreted from urine. "
4.	Obesity 01/01/2022 - "Of the 9 patients with refractory GP, 7 were malnourished and 2 had obesity. "
5.	Neoplasms (Cancer) 05/01/1995 - "The concentrition of GP-7 in tumor was higher." 05/01/1995 - "The level of GP-7 was higher in tumor than in kidney, spleen, and bone marrow after ip 20 mg.kg-1 for 10 d. "

Related Drugs and Biologics

1.	Inosine Triphosphate (ITP)
2.	Immunoglobulin M (IgM)
3.	Immunoglobulin G (IgG)
4.	Immunoglobulin A (IgA)
5.	Epitopes
6.	Agglutinins
7.	RNA (Ribonucleic Acid)
8.	Proteins (Proteins, Gene)
9.	Powders
10.	Etoposide (VP 16)