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NPC 17731

bradykinin receptor antagonist

Also Known As:

Arg-Arg-Pro-Hyp-Gly-Phe-Ser-HypE (transpropyl)-Oic-Arg; NPC-17731

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - NPC 17731: 7

Related Diseases

1.	Ischemia 12/01/1994 - "In addition, a kinin B2-receptor antagonist (NPC-17731; 40 micrograms/kg i.v.) attenuated activity of afferents during ischemia (0.39 +/- 0.08 vs. pre-NPC-17731, 0.72 +/- 0.13 impulses/s; P < 0.05) and eliminated the response of 10 C fibers to BK. "
2.	Asthma (Bronchial Asthma) 05/01/1997 - "Our objective was to study the effectiveness of NPC 17731 as a specific bradykinin beta 2-receptor antagonist and as an antagonist of the allergen-induced early phase of asthma. "
3.	Respiratory Hypersensitivity 05/01/1998 - "NPC-17731 (100 microg/kg) inhibited the antigen-induced airway hyperresponsiveness and the increase in eosinophils in BAL fluids. "
4.	Pain (Aches) 09/01/1993 - "4. The new potent and selective B2 receptor antagonists, Hoe 140 (D-Arg[Hyp3,Thi5,D-Tic7,Oic8]-BK), NPC 17731 (D-Arg[Hyp3, trans-4-propoxy-D-proline (transpropyl)7, Oic8]-BK), and NPC 17761 (D-Arg[Hyp3, trans-4-propoxy-D-proline (trans thiophenyl)7, Oic8]-BK) (0.02 to 1.0 nmol/paw), also caused significant inhibitions of both phases of formalin-induced pain. " 09/01/1993 - "In contrast, in domethacin (2.7 to 27 micromol kg-1) antagonized only the second phase of formalin-induced pain.6. The B2 receptor antagonists, Hoe 140, NPC 17731, NPC 17761, NPC 349 and NPC 567, all caused a significant inhibition of formalin-induced hindpaw oedema. "
5.	Inflammation (Inflammations) 01/01/1999 - "The effects of several drugs (terfenadine, bradykinin B2 receptor antagonists: HOE 140, NPC 17731, diacerein, indomethacin, meloxicam, nabumetone, and dexamethasone) upon myeloperoxidase and nitrate levels were analyzed in an inflammation model characterized by biphasic peaks (4 and 48 h) of cell migration and of fluid leakage. "

Related Drugs and Biologics

1.	Kinins
2.	Bradykinin
3.	Allergens
4.	icatibant
5.	Bradykinin B2 Receptor Antagonists
6.	Terfenadine (Seldane)
7.	Proline (L-Proline)
8.	Nitrates
9.	Peroxidase (Myeloperoxidase)
10.	Indomethacin (Indometacin)