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5- aminocarbonyl- 10,11- dihydro- 5H- dibenzo(a,d)cyclohepten- 5,10- imine (ADCI)

structure given in first source; n-methyl aspartate antagonist
Also Known As:
ADCI; SGB 017; SGB-017
Networked: 24 relevant articles (5 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Druilhe, Pierre: 4 articles (01/2011 - 09/2004)
2. Theisen, Michael: 3 articles (04/2015 - 09/2004)
3. Kim, Hee Jin: 3 articles (02/2015 - 05/2013)
4. Na, Duk L: 3 articles (02/2015 - 05/2013)
5. Kim, Sung Tae: 3 articles (02/2015 - 05/2013)
6. Seo, Sang Won: 3 articles (02/2015 - 05/2013)
7. Werring, David J: 3 articles (02/2015 - 05/2013)
8. Park, Jae-Hyun: 2 articles (02/2015 - 05/2013)
9. Kim, Jung-Hyun: 2 articles (02/2015 - 11/2013)
10. Weiner, Michael W: 2 articles (11/2013 - 05/2013)

Related Diseases

1. Epilepsy (Aura)
2. Seizures (Seizure)
3. Malaria
4. Parasitemia
10/01/2009 - "In the group of patients with the highest percentages and absolute numbers of CD14(hi)CCR2+CX3CR1+ MO and the highest mean levels of ADCI activity, blood parasitemias were lower (0.14+/-0.34%) than in the second group (1.30+/-3.34%; p = 0.0053). "
08/01/2011 - "Interestingly, in the ADCI test, higher levels of tumour necrosis factor alpha (TNF-α) were observed in the supernatant from cultures with higher parasitemias. "
05/01/2001 - "The results suggest that, among the different isotypes present in the serum of semi-immune individuals, parasite antigen-specific IgG3 in particular may play an important role in controlling parasitemia via an ADCI mechanism involving monocyte- derived mediators."
08/01/1995 - "Results obtained so far suggest that (a) merozoite uptake by monocytes (MN) as well as by polymorphonuclear cells has little influence on the course of parasitemia; (b) the ADCI effect is mediated by a soluble factor released by MN; (c) this or these factors are able to block the division of surrounding intraerythrocytic parasites at the one nucleus stage; (d) the critical triggering antigen(s) targeted by effective Abs would appear to be associated with the surface of merozoites, as opposed to that of infected red blood cells; (e) the MN receptor for Abs effective in ADCI is apparently Fc gamma RII, and not RI; (f) MN function is up- and down-regulated by interferon-gamma and interleukin 4, respectively; and (g) of several potential mediators released by MN, only tumor necrosis factor (TNF) proved of relevance. "
5. Alzheimer Disease (Alzheimer's Disease)

Related Drugs and Biologics

1. N-Methylaspartate (NMDA)
2. Sodium Channels (Sodium Channel)
3. Immunoglobulin G (IgG)
4. Antigens
5. IgG Receptors (Fc gamma RI)
6. Interleukin-4 (Interleukin 4)
7. 4-Aminopyridine (4 Aminopyridine)
8. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9. Pentylenetetrazole (Metrazol)
10. Interferon-gamma (Interferon, gamma)