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N-(2,3-dihydro-1H-inden-1-yl)adenosine
structure given in first source; RN given refers to cpd without isomeric designation;an adenosine agonist
Also Known As:
CI 947; CI-947; N-(2,3-dihydro-1H-inden-1-yl)adenosine, (R)-isomer; PD 117519; PD-117519
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purine Nucleosides: 360
Adenosine: 12431
N-(2,3-dihydro-1H-inden-1-yl)adenosine: 2
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Purine Nucleosides: 360
Adenosine: 12431
N-(2,3-dihydro-1H-inden-1-yl)adenosine: 2
Ribonucleosides: 49
Adenosine: 12431
N-(2,3-dihydro-1H-inden-1-yl)adenosine: 2
Related Diseases
1.
Body Weight (Weight, Body)
05/01/1998 - "
An adenosine agonist, designated chemically as (R)-N-(2,3-dihydro-1H-inden-1-yl) adenosine or CI-947, was administered orally to 2 males and 2 female cynomolgus monkeys each at 5, 10, 20, and 50 mg/kg of body weight for 2 wk. One male and 1 female given 50 mg/kg were euthanatized on days 10 and 8, respectively, because of poor clinical condition.
"
01/01/1991 - "
An adenosine agonist, designated chemically as (R)-N-(2,3-dihydro-1H-inden- 1-yl) adenosine, or CI-947, was administered to 3 male and 3 female beagles in oral doses of 5 mg/kg body weight.
"
2.
Vascular System Injuries
05/01/1998 - "
Coronary vascular injury in the monkey was similar to the arterial lesion in CI-947-treated dogs and may relate to the pharmacologic/hemodynamic effects induced by CI-947.
"
3.
Necrosis
05/01/1998 - "
Similar arterial lesions were present in the small and large intestines and testis of the male at 50 mg/kg. Colonic mucosal erosions with mixed inflammatory cell infiltrates in the lamina propria were seen in this male and in all CI-947 treated females at 10, 20, and 50 mg/kg. Myocardial degeneration and necrosis of myocardial fibers with mononuclear cell infiltrates in the interstititum were noted in the left ventricle of 1 female at 20 mg/kg and in all animals at 50 mg/kg. Renal cortical tubular dilatation with increases in serum creatinine and/or blood urea nitrogen were noted in a control female and animals at 10 and 50 mg/kg. Plasma CI-947 concentration increased with increasing dose.
"
Related Drugs and Biologics
1.
Adenosine (Adenocard)
2.
Urea (Carbamide)
3.
Nitrogen
4.
Dihydrotachysterol (AT 10)
5.
Creatinine