scalaradial

RN refers to the (5alpha,12alpha,17abeta)-isomer; a marine natural product isolated from the sponge Cacospongia sp.; structure given in first source

Also Known As:

12-(acetyloxy)-4,4,8-trimethylhomoandrost-16-ene-17,17a-dicarboxaldehyde

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

1.	Fleig, Andrea: 1 article (10/2017)
2.	Goto, Jun-Ichi: 1 article (10/2017)
3.	Horgen, F David: 1 article (10/2017)
4.	Kawabata, Kelly Galbraith: 1 article (10/2017)
5.	Kelly, Michelle: 1 article (10/2017)
6.	Layugan, Kristine: 1 article (10/2017)
7.	Myers, George: 1 article (10/2017)
8.	Penner, Reinhold: 1 article (10/2017)
9.	Poerzgen, Peter: 1 article (10/2017)
10.	Starkus, John G: 1 article (10/2017)

1.	Neoplasms (Cancer) 01/01/2012 - "In conclusion, scalaradial and cacospongionolide, by determining human cancer cell apoptosis, may represent new promising compounds to inhibit cancer cell proliferation."
2.	Insulinoma 10/27/2017 - "In addition, scalaradial was shown to inhibit endogenous TRPM2 currents in a rat insulinoma cell line (IC50 330 nM). "
3.	Inflammation (Inflammations) 01/01/2012 - "Besides marine natural products that inhibit PLA(2) are manoalide and its derivatives such as scalaradial and related compounds, pseudopterosins and vidalols, tetracylne from synthetic chemicals etc. There is an overview of the role of PLA(2) in inflammation that provides a rationale for seeking inhibitors of PLA(2) as anti-inflammatory agents. "
4.	Edema (Dropsy) 01/01/1995 - "PMA-induced ear edema was effectively inhibited by scalaradial, luffariellolide and aristolochic acid (ED50 = 70, 50 and 50 micrograms/ear, respectively) whereas ellagic acid was less effective (ED50 = 230 micrograms/ear). "
5.	Contact Dermatitis (Eczema, Contact) 01/01/1995 - "In the mouse model of oxazolone contact hypersensitivity, these PLA2 inhibitors have little effect (< or = 30% inhibition at 400 micrograms/ear) with scalaradial and luffariellolide being less effective than either aristolochic or ellagic acid. "

1.	Oxazolone
2.	Ellagic Acid
3.	Anti-Inflammatory Agents (Anti-Inflammatories)
4.	luffariellolide
5.	pseudopterosins
6.	manoalide
7.	aristolochic acid I (aristolochic acid)