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usambarensine

structure given in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - usambarensine: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - usambarensine: 3

Related Diseases

1.	Experimental Melanoma 11/01/1999 - "Usambarensine is highly toxic to B16 melanoma cells and inhibits the growth of leukemia and carcinoma cells. " 05/01/1996 - "The cytotoxicity and the selective antiprotozoal activity of some Strychnos alkaloids, namely strychnopentamine (SP) and usambarensine (US) (7) led us to analyze and compare their effects with emetine (EM) by using mouse B16 melanoma cells cultivated in vitro. "
2.	Melanoma (Melanoma, Malignant) 11/01/1999 - "However, its capacity to inhibit nucleic acids synthesis in melanoma cells, on the one hand, and its structural analogy with DNA-binding pyridoindole plant alkaloids recently studied (cryptolepine and matadine), on the other hand, suggested that usambarensine could also bind to DNA. "
3.	Malaria 01/01/2022 - "The exploration of the molecular network revealed the presence of alkaloids still unknown, and potentially active against malaria, in particular alkaloids close to usambarensine and its derivatives. "
4.	Leukemia 11/01/1999 - "Usambarensine is highly toxic to B16 melanoma cells and inhibits the growth of leukemia and carcinoma cells. " 11/01/1999 - "Usambarensine is thus characterized as DNA intercalator inducing apoptosis in leukemia cells." 11/01/1999 - "The plant alkaloid usambarensine intercalates into DNA and induces apoptosis in human HL60 leukemia cells." 11/01/1999 - "Biochemical experiments indicated that, in contrast to cryptolepine and matadine, usambarensine does not interfere with the catalytic activity of topoisomerase II. Human HL60 leukemia cells were used to assess the cytotoxicity of the alkaloid and its effect on the cell cycle. "
5.	Carcinoma (Carcinomatosis) 11/01/1999 - "Usambarensine is highly toxic to B16 melanoma cells and inhibits the growth of leukemia and carcinoma cells. "

Related Drugs and Biologics

1.	Alkaloids
2.	Nucleic Acids
3.	Intercalating Agents
4.	Emetine
5.	Type II DNA Topoisomerases (Topoisomerase II)
6.	DNA (Deoxyribonucleic Acid)
7.	matadine
8.	strychnopentamine
9.	cryptolepine