|1.||Demetzos, Costas: 4 articles (09/2011 - 01/2006)|
|2.||Dimas, Konstantinos: 4 articles (09/2011 - 01/2006)|
|3.||Georgopoulos, Aristidis: 3 articles (04/2007 - 01/2006)|
|4.||Hatziantoniou, Sophia: 3 articles (04/2007 - 01/2006)|
|5.||Noori, Shokoofe: 2 articles (03/2013 - 01/2010)|
|6.||Alevizopoulos, Konstantinos: 2 articles (09/2011 - 04/2007)|
|7.||Pantazis, Panayotis: 2 articles (09/2011 - 04/2007)|
|8.||Yu, Hua-Long: 1 article (06/2015)|
|9.||Wang, Zhi-Yong: 1 article (06/2015)|
|10.||Wang, Lin: 1 article (06/2015)|
|2.||Osteosarcoma (Osteogenic Sarcoma)
06/01/2015 - "The objective of the current study was to evaluate the antiproliferative activity of sclareol against MG63 osteosarcoma cells. "
06/01/2015 - "In summary, sclareol inhibits the growth of osteosarcoma cancer cells via the induction of apoptosis, which is accompanied by G1‑phase cell cycle arrest and loss of ΛΨm. "
06/01/2015 - "Fluorescence microscopy was used to detect the morphological changes in the MG63 osteosarcoma cancer cells and the appearance of apoptotic bodies following sclareol treatment. "
06/01/2015 - "Sclareol, a plant diterpene, exhibits potent antiproliferative effects via the induction of apoptosis and mitochondrial membrane potential loss in osteosarcoma cancer cells."
06/01/2015 - "The results revealed that sclareol induced dose‑ and time‑dependent growth inhibition of MG63 cancer cells with an IC50 value of 65.2 µM following a 12‑h incubation. "
03/01/2013 - "Our results suggest that Sclareol, by reducing Treg cells frequency and also tumor size can enhance the effect of cancer therapy as an immuno-stimulant."
03/01/2013 - "We also assessed if intraperitoneally injected Sclareol could improve the outcome of cancer therapy through suppressing the regulatory T cells. "
03/01/2013 - "Intraperitoneally injected Sclareol effects on reducing the tumor volume and shifting the cytokine profile were investigated. "
09/01/2011 - "In conclusion, we demonstrate herein that sclareol kills human tumor cells by inducing arrest at the G(1)-phase of the cell cycle followed by apoptosis that involves activation of caspases-8, -9 and -3 via a p53-independent mechanism. "
|4.||Colonic Neoplasms (Colon Cancer)
09/01/2011 - "Finally, the anticancer ability of sclareol in vivo was assessed by using human colon cancer xenograft/mouse models. "
04/01/2007 - "Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice."
04/01/2007 - "Here, we demonstrate that addition of sclareol to cultures of human colon cancer HCT116 cells results in inhibition of DNA synthesis, arrest of cells at the G(1) phase of the cell cycle, activation of caspases-8, -9, PARP degradation, and DNA fragmentation, events characteristic of induction of apoptosis. "
09/01/2011 - "The labdane diterpene sclareol has demonstrated significant cytotoxicity against human tumor cell lines and human colon cancer xenografts. "
01/01/2006 - "Liposomes incorporating sclareol at a drug to lipid molar ratio of 0:43, suggesting an incorporation efficiency of almost 80%, showed reduced growth rate of human colon cancer tumors (HCT116) developed in SCID mice, without any significant side effects."
|5.||Breast Neoplasms (Breast Cancer)
03/01/2013 - "Sclareol reduces CD4+ CD25+ FoxP3+ Treg cells in a breast cancer model in vivo."
04/01/2006 - "Here, we report the effect of sclareol against the human breast cancer cell lines MN1 and MDD2 derived from the parental cell line, MCF7. "
04/01/2006 - "Labd-14-ene-8,13-diol (sclareol) induces cell cycle arrest and apoptosis in human breast cancer cells and enhances the activity of anticancer drugs."
03/01/2013 - "To investigate the immunotherapeutic effectiveness of Sclareol against breast cancer by direct intraperitoneal injection. "
01/01/2010 - "By all means, the findings confirmed that the activity of Sclareol could reduce the tumor growth in vivo against breast cancer."
|4.||Nuclear Proteins (Protein, Nuclear)
|5.||Etoposide (VP 16)
|7.||DNA (Deoxyribonucleic Acid)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Transplantation (Transplant Recipients)