HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
MCI 727
structure given in first source
Also Known As:
2-(4-methylpiperazin-1-yl)-1-4-(2-phenylethyl)phenylethanone oxime; MCI-727; Ethanone, 2-(4-methyl-1-piperazinyl)-1-(4-(2-phenylethyl)phenyl)-, oxime, monohydrochloride, (Z)-
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Hydroxylamines: 16
Oximes: 1292
MCI 727: 3
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Piperazines: 26
MCI 727: 3
Related Diseases
1.
Ulcer
08/01/1991 - "
Effects of MCI-727, a new anti-ulcer agent, on plasma secretin concentration in rats and dogs and pancreatic exocrine secretion in rats.
"
08/01/1991 - "
In the present study, we investigated the effects of MCI-727, a new anti-ulcer agent, on plasma immunoreactive secretin concentration in rats and dogs using secretin specific RIA with the ethanol extraction method.
"
2.
Stomach Ulcer (Gastric Ulcer)
04/01/1991 - "
Repeated administration of MCI-727 (0.3-3 mg/kg/day, p.o., for 10 days) significantly promoted the spontaneous healing of acetic acid-induced chronic gastric ulcers.
"
3.
Spontaneous Remission
04/01/1991 - "
Repeated administration of MCI-727 (0.3-3 mg/kg/day, p.o., for 10 days) significantly promoted the spontaneous healing of acetic acid-induced chronic gastric ulcers.
"
4.
Pancreatitis
03/01/1996 - "
Effects of MCI-727 on pancreatic exocrine secretion and acute pancreatitis in two experimental rat models.
"
03/01/1996 - "
However, MCI-727 had no apparent beneficial effects on the biochemical and histologic alterations of acute pancreatitis in the severe form induced by retrograde intraductal injection of 1.0 ml/kg body wt of 4% sodium taurocholate.
"
03/01/1996 - "
In addition, even when administered immediately after the last cerulein injection, MCI-727 effectively ameliorated all these alterations of acute pancreatitis.
"
03/01/1996 - "
These findings suggest that oral administration of MCI-727 stimulates pancreatic exocrine secretion by endogenous secretin release and that it has therapeutic as well as preventive effects on mild forms of acute pancreatitis in rats.
"
03/01/1996 - "
In rats with acute pancreatitis induced by four subcutaneous injections of 20 mu g/kg body wt cerulein at hourly intervals over 3 h, MCI-727 administered orally at a dose of 100 mg/kg body wt 30 min before the first cerulein injection significantly reduced the increases in serum amylase and lipase activity and pancreatic wet weight and induced improvements in the results of histologic examination.
"
5.
Body Weight (Weight, Body)
03/01/1996 - "
Intraduodenal administration of MCI-727 [25, 50, or 100 mg/kg body weight (wt)] stimulated a dose-dependent increase in pancreatic juice and bicarbonate output without increasing the protein output or plasma cholecystokinin concentration.
"
Related Drugs and Biologics
1.
Secretin
2.
Ethanol (Ethyl Alcohol)
3.
Acetic Acid (Vinegar)
4.
Taurocholic Acid (Sodium Taurocholate)
5.
Proteins (Proteins, Gene)
6.
Lipase (Acid Lipase)
7.
Cholecystokinin (Pancreozymin)
8.
Ceruletide
9.
Bicarbonates (Hydrogen Carbonate)
10.
Amylases
Related Therapies and Procedures
1.
Subcutaneous Injections
2.
Oral Administration