|1.||Chung, June-Key: 19 articles (01/2015 - 07/2002)|
|2.||Spitzweg, Christine: 17 articles (12/2015 - 11/2003)|
|3.||Russell, Stephen J: 16 articles (04/2015 - 12/2003)|
|4.||Morris, John C: 16 articles (10/2014 - 11/2003)|
|5.||Filetti, Sebastiano: 16 articles (08/2014 - 01/2002)|
|6.||Morris, J C: 16 articles (12/2012 - 06/2000)|
|7.||Russo, Diego: 15 articles (08/2014 - 06/2002)|
|8.||Göke, Burkhard: 13 articles (04/2015 - 11/2007)|
|9.||Kang, Joo Hyun: 12 articles (07/2015 - 07/2004)|
|10.||Willhauck, Michael J: 12 articles (08/2013 - 11/2007)|
10/01/2009 - "We recently reported the significant therapeutic efficacy of radioiodine therapy in various tumor mouse models following transcriptionally targeted sodium iodide symporter (NIS) gene transfer. "
12/01/2008 - "Although the success of sodium/iodide symporter (NIS) gene-based cancer therapy is critically dependent on the level of radioiodide accumulation attained, recent evidence indicates that successful therapy relies not solely on NIS amount but also crucially on its functional activity. "
08/01/2015 - "Sodium iodide symporter was expressed in the cytoplasm with low intensity in most of the tumor specimens examined in this study. "
12/01/2011 - "The aim of the current study in the same HCC model was to evaluate the potential of biodegradable nanoparticle vectors based on pseudodendritic oligoamines (G2-HD-OEI) for systemic sodium iodide symporter (NIS) gene delivery and to compare efficiency and tumor specificity with LPEI-PEG-GE11. "
07/01/2007 - "This study aims to restore the iodide uptake by transferring and expressing human sodium iodide symporter (hNIS) in these cancer cells for 131I gene therapy. "
|2.||Thyroid Neoplasms (Thyroid Cancer)
07/01/2006 - "Accumulation of (131)I mediated by the sodium iodide symporter (NIS) provides a highly effective treatment for well-differentiated thyroid carcinoma. "
03/01/2004 - "The transcriptional regulation of the human sodium/iodide symporter (NIS) gene in normal and transformed thyroid cells is a crucial issue in attempting to restore iodide uptake and use radioiodine as a therapeutic treatment of thyroid cancer. "
01/01/2015 - "The function of membrane-localized sodium iodide symporter (NIS) determines the efficacy of radioiodine therapy in thyroid cancer. "
08/01/2014 - "Predictive role of nontumoral sodium iodide symporter activity and preoperative thyroid characteristics in remission process of thyroid cancer patients."
04/01/2012 - "Furthermore, PTTG over-expression negatively impacts upon the efficacy of radioiodine therapy in thyroid cancer, through repression of expression and function of the sodium iodide symporter. "
|3.||Breast Neoplasms (Breast Cancer)
02/01/2014 - "We investigated the therapeutic efficacy of a replication-competent oncolytic vaccinia virus, GLV-1h153, carrying human sodium iodide symporter (hNIS), in combination with radioiodine in an orthotopic triple-negative breast cancer (TNBC) murine model. "
03/01/2013 - "Recent studies have shown that breast cancer also expresses Sodium Iodide Symporter (NIS) gene, like in the thyroid, which is the factor responsible for the uptake of iodide by the thyroid, enabling radioiodine therapy of thyroid disorders. "
07/01/2011 - "This study aimed to introduce MSC-mediated expression of the sodium iodide symporter (NIS) for imaging and therapy of breast cancer. "
08/01/2013 - "Iodide has the strongest inhibitory effect on TRPM7 at physiological [Mg(2+)]i. Iodide also inhibits endogenous TRPM7-like currents as assessed in MCF-7 breast cancer cells, where upregulation of SLC5A5 sodium-iodide symporter enhances iodide uptake and inhibits cell proliferation. "
04/01/2013 - "Interestingly, NIS protein level was correlated with MEK/ERK activation in human breast tumors from a tissue microarray. "
|4.||Prostatic Neoplasms (Prostate Cancer)
04/01/2007 - "Design considerations for incorporating sodium iodide symporter reporter gene imaging into prostate cancer gene therapy trials."
08/01/2013 - "HSV-NIS, an oncolytic herpes simplex virus type 1 encoding human sodium iodide symporter for preclinical prostate cancer radiovirotherapy."
12/01/2012 - "A steep radioiodine dose response scalable to humans in sodium-iodide symporter (NIS)-mediated radiovirotherapy for prostate cancer."
10/01/2010 - "[Radioiodide treatment mediated by adenovirus transfer of human sodium iodide symporter gene into androgen-independent prostate cancer]."
04/01/2010 - "NIS protein was expressed in 41 of 78 prostate cancer (52.4%) and was located predominantly intracellularly, whereas immunoreactivity was missing in nontumor hyperplastic prostatic tissue. "
|5.||Hepatocellular Carcinoma (Hepatoma)
06/01/2013 - "Sodium iodide symporter (NIS)-mediated radiovirotherapy of hepatocellular cancer using a conditionally replicating adenovirus."
03/01/2013 - "Stromal targeting of sodium iodide symporter using mesenchymal stem cells allows enhanced imaging and therapy of hepatocellular carcinoma."
05/01/2006 - "Herein, we investigated the feasibility of monitoring human sodium iodide symporter (hNIS) gene expression with 99mTc-pertechnetate in hepatoma cells (MH3924A) following tissue-specific expression. "
05/01/2006 - "99mTc-pertechnetate uptake in hepatoma cells due to tissue-specific human sodium iodide symporter gene expression."
05/01/2006 - "We investigated the feasibility of radioiodine therapy targeting hepatoma cells (MH3924A) by tissue-specific expression of the human sodium/iodide symporter (hNIS) gene directed by the murine albumin enhancer and promoter (mAlb). "
|1.||Sodium Pertechnetate Tc 99m (Pertechnetate)
|5.||Prostate-Specific Antigen (Semenogelase)
|6.||Protein Kinases (Protein Kinase)
|1.||Heterologous Transplantation (Xenotransplantation)
|4.||Transplantation (Transplant Recipients)